Brosselin P, Rudant J, Orsi L, Leverger G, Baruchel A, Bertrand Y, Nelken B, Robert A, Michel G, Margueritte G, Perel Y, Mechinaud F, Bordigoni P, Hémon D, Clavel J
INSERM U754, 16, Avenue Paul Vaillant Couturier, F-94807 Villejuif Cedex, France.
Occup Environ Med. 2009 Sep;66(9):598-606. doi: 10.1136/oem.2008.042432. Epub 2009 Feb 12.
The association between acute childhood leukaemia and residing next to petrol stations and automotive repair garages was analysed in a national registry-based case-control study carried out in France in 2003-2004.
Population controls were frequency matched with cases on age and gender. Data were collected by standardised telephone interview with the mothers. The latter were asked to report the proximity of their homes to petrol stations, automotive repair garages and other businesses from the conception of the index child to the diagnosis (for cases) or interview (for controls). Odds ratios were estimated using unconditional regression models adjusted for age, gender, number of children under 15 years of age in the household, degree of urbanisation and type of housing.
765 cases of acute leukaemia and 1681 controls were included. Acute leukaemia was significantly associated with residence next to petrol stations or automotive repair garages (OR 1.6, 95% CI 1.2 to 2.2) and next to a petrol station (OR 1.9, 95% CI 1.2 to 3.0). The OR showed no tendency to increase with duration of exposure. The results were not modified by adjustment for potential confounding factors including urban/rural status and type of housing.
The results support the findings of our previous study and suggest that living next to a petrol station may be associated with acute childhood leukaemia. The results also suggest that the role of low-level exposure to benzene in acute childhood leukaemia deserves further evaluation.
在2003年至2004年于法国开展的一项基于全国登记处的病例对照研究中，分析了儿童急性白血病与居住在加油站和汽车修理店附近之间的关联。
按年龄和性别将人群对照与病例进行频数匹配。通过对母亲进行标准化电话访谈收集数据。要求母亲们报告从索引儿童受孕到诊断（对于病例）或访谈（对于对照）期间其家与加油站、汽车修理店及其他企业的距离。使用经年龄、性别、家庭中15岁以下儿童数量、城市化程度和住房类型调整的无条件回归模型估计比值比。
纳入了765例急性白血病病例和1681名对照。急性白血病与居住在加油站或汽车修理店附近（比值比1.6，95%可信区间1.2至2.2）以及居住在加油站附近（比值比1.9，95%可信区间1.2至3.0）显著相关。比值比未显示出随暴露持续时间增加的趋势。对包括城乡状况和住房类型在内的潜在混杂因素进行调整后，结果未改变。
这些结果支持了我们之前研究的发现，并表明居住在加油站附近可能与儿童急性白血病有关。结果还表明，低水平接触苯在儿童急性白血病中的作用值得进一步评估。
