Inase N, Takayama S, Nakayama M, Miura H, Kimula Y
Department of Internal Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan.
J Surg Oncol. 1991 Oct;48(2):145-7. doi: 10.1002/jso.2930480215.
A case of pulmonary clear cell carcinoma is demonstrated. A large left lower lobe mass, without lymphadenopathy was detected on a screening chest X-ray, and a left lower lobectomy was performed. The tumor was composed predominantly of clear cells with some areas showing cells typical for small cell carcinoma. Ultrastructurally, the larger clear cell had cytoplasm containing many rough endoplasmic reticuli and free ribosomes, while the smaller dark cell showed a serrated nucleus and scanty cytoplasm having many free ribosomes without neurosecretory granules. This is the first report on pulmonary clear cell carcinoma with small cell carcinoma patterns, and this case will throw doubt on the conclusion of previous studies that clear cell carcinoma is not a separate entity.
本文展示了一例肺透明细胞癌病例。在胸部X线筛查中发现左肺下叶有一个较大肿块，无淋巴结肿大，遂行左肺下叶切除术。肿瘤主要由透明细胞组成，部分区域可见小细胞癌典型细胞。超微结构显示，较大的透明细胞胞质内含有许多粗面内质网和游离核糖体，而较小的暗细胞可见锯齿状核，胞质稀少，有许多游离核糖体，但无神经分泌颗粒。这是首例关于具有小细胞癌形态的肺透明细胞癌的报道，该病例将使之前关于透明细胞癌并非独立实体的研究结论受到质疑。
