具有功能化外壳的胶体金对选择素结合的抑制作用。
Inhibition of selectin binding by colloidal gold with functionalized shells.
作者信息
Dernedde Jens, Enders Sven, Reissig Hans-Ulrich, Roskamp Meike, Schlecht Sabine, Yekta Shahla
机构信息
Charité-Universitätsmedizin Berlin, CBF, Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, Hindenburgdamm 30, 12203 Berlin, Germany.
出版信息
Chem Commun (Camb). 2009 Feb 28(8):932-4. doi: 10.1039/b818263a. Epub 2009 Jan 15.
DOI:10.1039/b818263a
PMID:19214320
Abstract
Gold colloids with terminally functionalized sulfated thiol shells were found to bind to P- and L-selectins with IC(50) values in the picomolar range; branched acyclic epitopes show the highest affinity, whereas a sulfated carbohydrate mimetic provides the best selectivity.
摘要
末端功能化硫酸化硫醇壳的金胶体被发现能与P-和L-选择素结合，其半数抑制浓度（IC50）值在皮摩尔范围内；支链无环表位显示出最高亲和力，而硫酸化碳水化合物模拟物则具有最佳选择性。
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