血糖生成指数和血糖负荷与老年人脑损伤无关。
Glycemic index and glycemic load are not associated with brain lesions in the elderly.
作者信息
Trone R J, Weaver K G, Steffens D C, Payne M E
机构信息
Department of Clinical Research, Campbell University, Morrisville, NC 27560, USA.
出版信息
J Nutr Health Aging. 2009 Feb;13(2):117-20. doi: 10.1007/s12603-009-0017-x.
OBJECTIVE
The goal of this study was to determine if brain lesion volume was correlated with dietary glycemic index and glycemic load in elderly individuals.
DESIGN AND SETTING
This cross-sectional study was performed at an academic medical center as part of a clinical study of late-life depression.
PARTICIPANTS
Subjects (n=137) were age 60 or over, and were participating as non-depressed comparison subjects.
MEASUREMENTS
Food intake was assessed using the Block 1998 food frequency questionnaire. Glycemic index and glycemic load measures were derived from reported food intake. Brain lesion volumes were calculated from magnetic resonance imaging (MRI).
RESULTS
No significant associations were found between glycemic index or glycemic load, and brain lesion volume.
CONCLUSION
Dietary glycemic measures may be unrelated to brain lesions or may be related to brain lesions only in individuals with impaired glycemic control or other vascular risk factors. Further studies are needed to confirm this finding and to determine if glycemic control moderates this association.
目的
本研究的目的是确定老年个体的脑损伤体积是否与饮食血糖指数和血糖负荷相关。
设计与背景
这项横断面研究在一所学术医疗中心进行，是晚年抑郁症临床研究的一部分。
参与者
受试者（n = 137）年龄在60岁及以上，作为非抑郁对照受试者参与研究。
测量方法
使用1998年版Block食物频率问卷评估食物摄入量。血糖指数和血糖负荷指标根据报告的食物摄入量得出。脑损伤体积通过磁共振成像（MRI）计算得出。
结果
未发现血糖指数或血糖负荷与脑损伤体积之间存在显著关联。
结论
饮食血糖指标可能与脑损伤无关，或者仅在血糖控制受损或有其他血管危险因素的个体中与脑损伤有关。需要进一步研究来证实这一发现，并确定血糖控制是否会调节这种关联。
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