Department of Obstetrics and Gynecology, School of Medicine, Yuzuncu Yil University, Van, Turkey.
Arch Gynecol Obstet. 2009 Oct;280(4):559-63. doi: 10.1007/s00404-009-0958-7. Epub 2009 Feb 13.
To investigate the correlation between serum 25-hydroxyvitamin D (25-OH-VD) concentrations and metabolic parameters in obese and non-obese women with polycystic ovary syndrome (PCOS).
One hundred women with PCOS were divided into two groups, obese and non-obese, according to their body mass index (BMI). Waist-to-hip ratio (WHR), Ferriman-Gallwey score, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, triglycerides, calcium, 25-OH-VD, LH/FSH, total testosterone, and DHEAS were measured.
The serum 25-OH-VD mean levels were 56.31% lower in the obese PCOS patients. There was an association of increased HOMA-IR, BMI, WHR, triglycerides, total testosterone, and DHEAS with decreased 25-OH-VD concentrations in the obese PCOS patients.
Low serum 25-OH-VD concentrations result from the presence of obesity and insulin resistance. However, the dependency between PCOS and hypovitaminosis D is questionable. Hypovitaminosis D should be kept in mind while managing obese women with PCOS.
研究肥胖和非肥胖多囊卵巢综合征（PCOS）妇女血清 25-羟维生素 D（25-OH-VD）浓度与代谢参数的相关性。
根据体重指数（BMI）将 100 名 PCOS 患者分为肥胖组和非肥胖组。测量腰臀比（WHR）、Ferriman-Gallwey 评分、胰岛素抵抗稳态模型评估（HOMA-IR）、总胆固醇、甘油三酯、钙、25-OH-VD、LH/FSH、总睾酮和 DHEAS。
肥胖 PCOS 患者的血清 25-OH-VD 平均水平低 56.31%。肥胖 PCOS 患者中，HOMA-IR、BMI、WHR、甘油三酯、总睾酮和 DHEAS 升高与 25-OH-VD 浓度降低有关。
低血清 25-OH-VD 浓度是由肥胖和胰岛素抵抗引起的。然而，PCOS 和维生素 D 缺乏之间的依赖性值得怀疑。在治疗肥胖的 PCOS 女性时应注意维生素 D 缺乏。
