Clarkin O M, Boyd D, Madigan S, Towler M R
Materials and Surface Science Institute, University of Limerick, National Technological Park, Limerick, Ireland.
J Mater Sci Mater Med. 2009 Jul;20(7):1563-70. doi: 10.1007/s10856-009-3701-9. Epub 2009 Feb 13.
Glass polyalkenoate cements based on strontium calcium zinc silicate glasses (Zn-GPCs) and high molecular weight polyacrylic acids (PAA) (MW; 52,000-210,000) have been shown to exhibit mechanical properties and in vitro bioactivity suitable for arthroplasty applications. Unfortunately, these formulations exhibit working times and setting times which are too short for invasive surgical applications such as bone void filling and fracture fixation. In this study, Zn-GPCs were formulated using a low molecular weight PAA (MW; 12,700) and a modifying agent, trisodium citrate dihydrate (TSC), with the aim of improving the rheological properties of Zn-GPCs. These novel formulations were then compared with commercial self-setting calcium phosphate cement, Hydroset, in terms of compressive strength, biaxial flexural strength and Young's modulus, as well as working time, setting time and injectability. The novel Zn-GPC formulations performed well, with prolonged mechanical strength (39 MPa, compression) greater than both vertebral bone (18.4 MPa) and the commercial control (14 MPa). However, working times (2 min) and rheological properties of Zn-GPCs, though improved, require further modifications prior to their use in minimally invasive surgical techniques.
基于锶钙锌硅酸盐玻璃（Zn - GPCs）和高分子量聚丙烯酸（PAA）（分子量；52,000 - 210,000）的玻璃聚链烯酸酯水泥已被证明具有适合关节置换应用的机械性能和体外生物活性。不幸的是，这些配方的工作时间和凝固时间对于诸如骨缺损填充和骨折固定等侵入性手术应用来说太短。在本研究中，使用低分子量PAA（分子量；12,700）和改性剂二水合柠檬酸三钠（TSC）配制Zn - GPCs，目的是改善Zn - GPCs的流变性能。然后将这些新型配方与市售自固化磷酸钙水泥Hydroset在抗压强度、双轴弯曲强度和杨氏模量以及工作时间、凝固时间和可注射性方面进行比较。新型Zn - GPC配方表现良好，其延长的机械强度（39 MPa，压缩）大于椎骨（18.4 MPa）和商业对照（14 MPa）。然而，Zn - GPCs的工作时间（2分钟）和流变性能虽然有所改善，但在用于微创手术技术之前还需要进一步改进。
