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不同粒径羟基磷灰石对用于骨修复的氯氧镁水泥耐水性的影响。

Effect of different-sizes of hydroxyapatite on the water resistance of magnesium oxychloride cement for bone repair.

作者信息

Guan Xiali, Zhou Gang, Cui Yangyang, Fei Jingjng, Fan Yubo

机构信息

School of Biological Science and Medical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beihang University Beijing 100083 China

Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University Beijing 102402 China.

出版信息

RSC Adv. 2019 Nov 26;9(66):38619-38628. doi: 10.1039/c9ra08200j. eCollection 2019 Nov 25.

DOI:10.1039/c9ra08200j
PMID:35540243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9075848/
Abstract

Magnesium oxychloride cement (MOC) has recently attracted significant attention due to its excellent mechanical properties and biological behavior. However, the applications of MOC have been limited by its poor water resistance. To solve this problem, micro-sized hydroxyapatite (μ-HA) and nano-sized hydroxyapatite (n-HA) were used to improve the water resistance of MOC. The microstructure, mechanical strength and tissue responses of three types of MOC were investigated. The results demonstrated that the lost strength of MOC-0, MOC/μ-HA and MOC/n-HA were 0.92 ± 0.04, 0.81 ± 0.02 and 0.55 ± 0.01 after immersing in SBF for 28 days. The contact angles of MOC-0, MOC/μ-HA and MOC/n-HA were 42.5 ± 4.76°, 50.3 ± 5.63° and 70.4 ± 6.59°, respectively. Compared to MOC-0 and MOC/μ-HA, the filling role of the n-HA in the cement was more favorable for the formation of 5 Mg(OH)·MgCl·8HO (phase 5) and a dense microstructure. In addition, the histological evaluation displayed that MOC/n-HA enhanced the efficiency of new bone formation. It also showed good biocompatibility and biodegradability . And MOC/n-HA had better osteogenic performance. Therefore, MOC/n-HA could be used as a potential bone void filler for irregular bone defects in clinical applications.

摘要

氯氧镁水泥（MOC）因其优异的力学性能和生物学性能，近年来受到了广泛关注。然而，MOC的应用受到其耐水性差的限制。为了解决这个问题，采用微米级羟基磷灰石（μ-HA）和纳米级羟基磷灰石（n-HA）来提高MOC的耐水性。研究了三种类型MOC的微观结构、力学强度和组织反应。结果表明，MOC-0、MOC/μ-HA和MOC/n-HA在模拟体液（SBF）中浸泡28天后的强度损失分别为0.92±0.04、0.81±0.02和0.55±0.01。MOC-0、MOC/μ-HA和MOC/n-HA的接触角分别为42.5±4.76°、50.3±5.63°和70.4±6.59°。与MOC-0和MOC/μ-HA相比，n-HA在水泥中的填充作用更有利于5Mg(OH)·MgCl·8H₂O（相5）的形成和致密微观结构的形成。此外，组织学评估显示，MOC/n-HA提高了新骨形成的效率。它还表现出良好的生物相容性和生物降解性。并且MOC/n-HA具有更好的成骨性能。因此，MOC/n-HA可作为临床应用中不规则骨缺损的潜在骨缺损填充材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/4bf3a272f1e1/c9ra08200j-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/1bd3f1387f3d/c9ra08200j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/d9b270fd1464/c9ra08200j-f2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/cbb728b14466/c9ra08200j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/b2331606ccf8/c9ra08200j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/1a88e489ac52/c9ra08200j-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/04678f2bffbd/c9ra08200j-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/4bf3a272f1e1/c9ra08200j-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/1bd3f1387f3d/c9ra08200j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/d9b270fd1464/c9ra08200j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/939d8d2038d2/c9ra08200j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/cbb728b14466/c9ra08200j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/b2331606ccf8/c9ra08200j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/1a88e489ac52/c9ra08200j-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/04678f2bffbd/c9ra08200j-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f51/9075848/4bf3a272f1e1/c9ra08200j-f8.jpg

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