Wada Hideo, Usui Masanobu, Sakuragawa Nobuo
Departments of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu-city, Japan.
Semin Thromb Hemost. 2008 Nov;34(8):772-8. doi: 10.1055/s-0029-1145259. Epub 2009 Feb 12.
Professor Eberhard F. Mammen greatly contributed to the understanding of the relationship between hemostatic abnormalities and liver diseases. The physiology of the hemostatic system is closely linked to liver function because the liver parenchymal cells produce most of the factors of the clotting and fibrinolytic systems. Acute or chronic hepatocellular diseases and hepatic failure including liver cirrhosis, vitamin K deficiency, liver surgery including liver transplantation, and sclerotherapy of bleeding esophageal varices, which were classified by Prof. Mammen, show various hemostatic abnormalities in the coagulation system, fibrinolytic system, platelets, and the reticuloendothelial system. Hemostatic abnormalities in patients with hepatic failure or in those that have undergone liver surgery are similar to those in disseminated intravascular coagulation. Prof. Mammen also contributed to the study of vitamin K-dependent clotting factors, antithrombin, and hemostatic molecular markers. Partly based on this work, the prothrombin time-international normalized ratio, several hemostatic molecular markers, and antithrombin therapy have been recently developed for the diagnosis and treatment of thrombosis.
埃伯哈德·F·马门教授为人们理解止血异常与肝脏疾病之间的关系做出了巨大贡献。止血系统的生理学与肝功能密切相关，因为肝实质细胞产生凝血和纤溶系统的大部分因子。马门教授所分类的急性或慢性肝细胞疾病及肝衰竭（包括肝硬化）、维生素K缺乏、肝脏手术（包括肝移植）以及出血性食管静脉曲张硬化疗法，在凝血系统、纤溶系统、血小板和网状内皮系统中呈现出各种止血异常。肝衰竭患者或接受肝脏手术患者的止血异常与弥散性血管内凝血患者的相似。马门教授还对维生素K依赖凝血因子、抗凝血酶及止血分子标志物的研究做出了贡献。部分基于这项工作，最近已开发出凝血酶原时间-国际标准化比值、多种止血分子标志物及抗凝血酶疗法用于血栓形成的诊断和治疗。
