印度假马齿苋三萜皂苷对东莨菪碱诱导的小鼠记忆损伤的影响。
Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice.
作者信息
Zhou Yun, Peng Ling, Zhang Wei-Dong, Kong De-Yun
机构信息
Zhejiang Food and Drug Administration, Hangzhou 310012, Zhejiang Province, PR China.
出版信息
Planta Med. 2009 May;75(6):568-74. doi: 10.1055/s-0029-1185339. Epub 2009 Feb 12.
PMID:19214943
Abstract
Three new saponins, bacopasides IX-XI (1- 3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice.
摘要
从假马齿苋的全株中分离出三种新的皂苷，即假马齿苋皂苷IX - XI（1 - 3），以及它们的已知类似物假马齿苋皂苷I（4）、假马齿苋皂苷II（5）、假马齿苋皂苷C（6）和假马齿苋皂苷D（7）。在小鼠东莨菪碱诱导的记忆损伤的莫里斯水迷宫试验和跳台试验中进行测试时，化合物3、4和6表现出益智活性。
Zotero 插件