Boulos Patrick R, Kelley John M, Falcão Marcele F, Tremblay Jean-Francois, Davis Roger B, Hatton Mark P, Rubin Peter A D
Department of Ophthalmology, Oculofacial Surgery Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
Dermatol Surg. 2009 Feb;35(2):229-39. doi: 10.1111/j.1524-4725.2008.34414.x.
A light-emitting diode (LED) photomodulation system can produce pulses of amber light expected to induce structural skin changes and reverse the effects of photoaging.
To reproduce the encouraging results already published.
Facial skin was exposed to pulses of 588+/-10-nm-wavelength light from a photomodulation device for 40 seconds once a week for 8 weeks. Photographs, clinical assessment, and a subjective questionnaire were taken at baseline, at the last follow-up, and 1 month after that. Thirty-six patients' pre- and post-treatment photos were arbitrarily scrambled, and 30 independent blinded observers were asked to pick the post-treatment photo. Two time-point comparisons were evaluated.
For every facial characteristic studied and for both time-point comparisons, patients reported highly statistically significant improvements. In extremely sharp contrast, neither the physician's assessment nor the independent observers' evaluation indicated any improvement.
Although subjective findings are comparable between studies, we were unable to reproduce the objective results of efficacy previously reported. Patients genuinely believed that several of their facial features had improved, even though there was no detectable objective change. Our data therefore suggest that the LED photomodulation treatment from the device tested is a placebo.
发光二极管（LED）光调制系统能够产生琥珀色光脉冲，有望引起皮肤结构变化并逆转光老化的影响。
重现已发表的令人鼓舞的结果。
使用光调制设备，每周一次将面部皮肤暴露于波长为588±10纳米的光脉冲下40秒，持续8周。在基线、最后一次随访时以及随访后1个月拍摄照片、进行临床评估并填写主观问卷。将36名患者治疗前后的照片随机打乱，让30名独立的盲法观察者挑选出治疗后的照片。评估两个时间点的比较情况。
对于所研究的每一项面部特征以及两个时间点的比较，患者报告的改善在统计学上都具有高度显著性。形成极其鲜明对比的是，医生的评估和独立观察者的评价均未表明有任何改善。
尽管不同研究中的主观结果具有可比性，但我们无法重现先前报道的客观疗效结果。患者确实认为他们的一些面部特征有所改善，尽管没有可检测到的客观变化。因此，我们的数据表明，所测试设备的LED光调制治疗是一种安慰剂。
