Theiss U, Kuhn I, Lücker P W
Inst. für Klinische Pharmakologie Bobenheim, Grünstadt, Germany.
Methods Find Exp Clin Pharmacol. 1991 Jun;13(5):353-9.
Transdermal application of drugs is a field of great importance in medical therapy. The application is painless and may be controlled at any time. Iontophoresis is one method for transdermal application of substances, especially for larger or charged molecules which cannot be administered by a simple transdermal route. The problems arise from the complex equipment and the electrical properties of the skin. A better understanding of skin structure and electric transmission through human skin has led to renewed interest in iontophoresis as an administration mode. Iontophoresis is the method of choice in administration of certain local anesthetics and has had its greatest success in therapy of hyperhidrosis. New applications are to be expected, particularly in administration of peptide and protein drugs.
药物的经皮给药是医学治疗中一个非常重要的领域。这种给药方式无痛，且可随时控制。离子电渗疗法是一种经皮给药的方法，尤其适用于那些无法通过简单经皮途径给药的较大分子或带电分子。问题在于设备复杂以及皮肤的电学特性。对皮肤结构和电信号通过人体皮肤传输的更好理解，使得人们对离子电渗疗法作为一种给药方式重新产生了兴趣。离子电渗疗法是某些局部麻醉药给药的首选方法，并且在多汗症治疗方面取得了最大的成功。预计会有新的应用，特别是在肽类和蛋白质药物的给药方面。
