Singh J, Roberts M S
Department of Pharmacy, University of Otago Medical School, Dunedin, New Zealand.
Drug Des Deliv. 1989 Jan;4(1):1-12.
The advantages and limitations, theory, and factors in the use of electric current to deliver drugs across the skin are discussed. Application of the technique in the delivery of local anaesthetics, antibiotics/antibacterials, mydriatics, vinca alkaloids, non-electrolytes, biogenic amines, peptides, and other agents is reviewed. It is concluded that the method alone, or in combination with phonophoresis (delivery via ultrasonic perturbation), offers considerable scope in the transdermal delivery of drugs.
讨论了利用电流透过皮肤给药的优点、局限性、原理及相关因素。综述了该技术在局部麻醉药、抗生素/抗菌药、散瞳药、长春花生物碱、非电解质、生物胺、肽及其他药物递送中的应用。得出的结论是，该方法单独使用或与超声导入法（通过超声扰动进行递送）相结合，在药物透皮递送方面具有广阔的应用前景。
