Zarrabeitia María T, Pinheiro Fátima, de Pancorbo Marian M, Cainé Laura, Cardoso Sergio, Gusmão Leonor, Riancho José A
Unit of Legal Medicine, University of Cantabria, Av Herrera Oria s/n, 39011 Santander, Spain.
Forensic Sci Int Genet. 2009 Mar;3(2):63-6. doi: 10.1016/j.fsigen.2008.10.001. Epub 2008 Nov 18.
We have applied a recently described X-STRs decaplex to characterize four population groups of the Iberian Peninsula, including two well mixed populations and two relatively isolated ones from Northern Spain, in order to get a better insight about the characteristics of X-STRs in those population types between-population differences in allelic frequencies were relatively small. Nevertheless, Fst values were between 0.2 and 2.7%, figures higher than usually reported for autosomic STRs. This result suggests that when forensic cases originate from relatively isolated groups in western Europe, and a specific reference database is not available, it is probably safe to include a Fst-based correction in the calculations of matching or kinship probabilities.
