微生物生物转化作为甘蔗蟾蜍类固醇毒素化学多样性的一个来源。
Microbial biotransformation as a source of chemical diversity in cane toad steroid toxins.
作者信息
Hayes R Andrew, Piggott Andrew M, Dalle Kristian, Capon Robert J
机构信息
Institute for Molecular Bioscience, The University of Queensland, Carmody Road, St. Lucia, Qld 4072, Australia.
出版信息
Bioorg Med Chem Lett. 2009 Mar 15;19(6):1790-2. doi: 10.1016/j.bmcl.2009.01.064. Epub 2009 Jan 27.
The cane toad is an invasive pest that is rapidly colonising northern Australia. The cane toad parotoid gland secretes cardiotoxic steroids (bufadienolides) that are poisoning native predator species. This study reveals bufadienolide diversity within the secretions of Australian cane toads is different to cane toads from overseas, being far more structurally diverse than previously assumed. It is proposed that this variation is mediated by in situ bacterial biotransformation.
蔗蟾蜍是一种入侵性害虫，正在迅速在澳大利亚北部扩散。蔗蟾蜍的腮腺分泌具有心脏毒性的类固醇（蟾毒配基），正在毒害当地的捕食性物种。这项研究表明，澳大利亚蔗蟾蜍分泌物中的蟾毒配基多样性与来自海外的蔗蟾蜍不同，其结构多样性远比之前认为的要高。研究提出，这种差异是由原位细菌生物转化介导的。
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