Smirnov A V, Entelis N S, Krasheninnikov I A, Martin R, Tarassov I A
Faculty of Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.
Biochemistry (Mosc). 2008 Dec;73(13):1418-37. doi: 10.1134/s000629790813004x.
Small non-coding RNAs are today a topic of great interest for molecular biologists because they can be regarded as relicts of a hypothetical "RNA world" which, apparently, preceded the modern stage of organic evolution on Earth. The small molecule of 5S rRNA (approximately 120 nucleotides) is a component of large ribosomal subunits of all living beings (5S rRNAs are not found only in mitoribosomes of fungi and metazoans). This molecule interacts with various protein factors and 23S (28S) rRNA. This review contains the accumulated data to date concerning 5S rRNA structure, interactions with other biological macromolecules, intracellular traffic, and functions in the cell.
如今，小分子非编码RNA是分子生物学家极为感兴趣的一个话题，因为它们可被视为一个假设的“RNA世界”的遗迹，显然，这个“RNA世界”先于地球上有机进化的现代阶段。5S rRNA的小分子（约120个核苷酸）是所有生物大核糖体亚基的一个组成部分（仅在真菌和后生动物的线粒体核糖体中未发现5S rRNA）。该分子与各种蛋白质因子和23S（28S）rRNA相互作用。这篇综述包含了迄今为止有关5S rRNA结构、与其他生物大分子的相互作用、细胞内运输以及在细胞中的功能的积累数据。
