Khoronenkova S V, Tishkov V I
Chemistry Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia.
Biochemistry (Mosc). 2008 Dec;73(13):1511-8. doi: 10.1134/s0006297908130105.
D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids. The most interesting and important data for regulation of the nervous system, hormone secretion, and other processes by D-amino acids as well as development of different diseases under changed DAAO activity are presented. The mechanism of regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects. Use of DAAO for diagnostic and therapeutic purposes is also considered.
D-氨基酸在活细胞中许多过程的调节中起着关键作用。依赖黄素腺嘌呤二核苷酸（FAD）的D-氨基酸氧化酶（DAAO）是负责维持D-氨基酸适当水平的最重要酶之一。文中介绍了关于D-氨基酸对神经系统、激素分泌及其他过程的调节以及DAAO活性改变时不同疾病发生发展的最有趣且重要的数据。调节机制复杂且多参数，因为同一酶同时影响不同D-氨基酸的水平，这可能导致相反的效应。还考虑了将DAAO用于诊断和治疗目的。
