Chen Ning, Li Hui, Zhao Li-Yun, Liu Jian-Bo, Huang Qin, Wang Tong-Han, Hao Xiao-Mei
Department of Respiratory Diseases, Guangdong Second Provincial Traditional Chinese Medicine Hospital, Guangzhou, Guangdong Province 510095, China.
Zhong Xi Yi Jie He Xue Bao. 2009 Feb;7(2):105-9. doi: 10.3736/jcim20090202.
To investigate the effects of traditional Chinese medicine (TCM) therapy for clearing heat and resolving phlegm on systemic inflammatory response syndrome (SIRS) in acute deterioration stage of chronic obstructive pulmonary disease (COPD) and the serum procalcitonin (PCT) level.
One hundred patients suffering from SIRS in acute deterioration stage of COPD were included and randomly divided into treatment group (50 cases) and control group (50 cases). Patients in the treatment group were treated with routine Western medicine and Chinese herbal medicine for clearing away heat and eliminating phlegm, while patients in the control group were treated with routine Western medicine only. Patients in the two groups were treated for one week. The serum PCT levels in the two groups were measured at days 1, 3, and 7, and clinical symptom scores were recorded at days 1 and 7 in hospital to determine the effects.
Clinical symptom scores in the two groups decreased after the treatment (P<0.05), and the symptom score in the treatment group was lower than that in the control group (P<0.05). The effect of integrated traditional Chinese and Western medicine treatment was obviously better than that of the Western medicine treatment when improving rates in clinical symptom score were divided into over 70% and less than 70% (P<0.05). Serum PCT concentration was in direct proportion to clinical symptom score (P<0.05). The patients with higher clinical symptom score were in more serious pathogenetic condition. There were no significant differences in the serum PCT concentrations among days 1, 3 and 7 in hospital.
The effect of TCM therapy for clearing heat and removing phlegm combined with Western medicine treatment is better than that of the Western medicine treatment. TCM therapy has a satisfied effect in improving clinical symptoms. The serum PCT concentration is correlated with the severity of SIRS in acute deterioration stage of COPD.
探讨清热化痰法中药治疗对慢性阻塞性肺疾病（COPD）急性加重期全身炎症反应综合征（SIRS）及血清降钙素原（PCT）水平的影响。
选取100例COPD急性加重期并发SIRS患者，随机分为治疗组（50例）和对照组（50例）。治疗组采用常规西药加清热化痰中药治疗，对照组仅采用常规西药治疗。两组均治疗1周。分别于治疗第1、3、7天检测两组患者血清PCT水平，于住院第1、7天记录临床症状评分以判定疗效。
两组治疗后临床症状评分均降低（P<0.05），且治疗组低于对照组（P<0.05）。将临床症状评分改善率分为>70%和<70%时，中西医结合治疗效果明显优于单纯西药治疗（P<0.05）。血清PCT浓度与临床症状评分呈正相关（P<0.05），临床症状评分越高病情越重。住院第1、3、7天血清PCT浓度差异无统计学意义。
清热化痰法中药联合西药治疗COPD急性加重期SIRS的效果优于单纯西药治疗，能有效改善临床症状，血清PCT浓度与COPD急性加重期SIRS严重程度相关。
