The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China.
Maternal and Child Health Care Hospital of Dongchangfu District, Liaocheng City Shandong Province, Liaocheng 252000, China.
J Healthc Eng. 2022 Mar 12;2022:3962074. doi: 10.1155/2022/3962074. eCollection 2022.
To observe the clinical efficacy of heat clearing phlegm mixture combined with vibration sputum excretion instrument in the treatment of patients with acute exacerbation of COPD with phlegm-heat obstructing lung, 90 patients with acute exacerbation of COPD are selected and divided into three groups, namely, control group, traditional medicine group, and combined group: the control group (conventional western medicine treatment), traditional medicine group (heat clearing and phlegm mixture), and combined group (heat clearing and phlegm mixture + vibratory sputum excretion instrument) with 30 cases each. All the patients in the three groups were given conventional western medicine treatment. On this basis, the traditional medicine group was given the oral administration of the heat-clearing and phlegm-clearing mixture, and the combined group was given the oral administration of the heat-clearing and phlegm-clearing mixture and the vibratory sputum discharge apparatus. Machine learning is used to classify the patients into three groups based on the characteristics of their biomarkers, physical attributes, and medical history. The TCM syndrome score, blood gas analysis, lung function, and inflammatory indexes of the three groups were compared. TCM syndrome scores of the three groups were all lower than before; both the combined group and the TCM group were better than the control group ( < 0.05). Although the improvement degree of the combined group was better than that of the TCM group, the difference was not statistically significant ( > 0.05). TCM syndrome effect is seen to be 96.55% in the combined group, 89.29% in the TCM group, and 63.33% in the control group. Blood gas analysis is also performed; PO2 and PCO2 of the three groups were significantly improved after treatment. The combination group was superior to the traditional medicine group and the control group ( < 0.05), and the traditional medicine group was superior to the control group ( < 0.05). It is concluded that the combination of heat clearing phlegm mixture and vibration sputum excretion instrument can improve TCM syndrome score, CAT score, blood gas analysis, lung function, and inflammatory indicators in patients with acute exacerbation of COPD with phlegm-heat obstructing lung.
观察清热化痰合剂联合振动排痰仪治疗痰热壅肺型 COPD 急性加重期的临床疗效，选择急性加重期 COPD 患者 90 例，分为三组，即对照组、中药组、联合组：对照组（常规西药治疗）、中药组（清热化痰合剂）和联合组（清热化痰合剂+振动排痰仪），每组 30 例。三组患者均给予常规西药治疗。在此基础上，中药组给予清热化痰合剂口服，联合组给予清热化痰合剂口服和振动排痰仪治疗。采用机器学习根据患者的生物标志物、身体属性和病史将患者分为三组。比较三组患者的 TCM 证候评分、血气分析、肺功能和炎症指标。三组 TCM 证候评分均低于治疗前；联合组和中药组均优于对照组（<0.05）。虽然联合组的改善程度优于中药组，但差异无统计学意义（>0.05）。联合组 TCM 证候疗效为 96.55%，中药组为 89.29%，对照组为 63.33%。血气分析也有改善；三组治疗后 PO2 和 PCO2 均明显改善。联合组优于中药组和对照组（<0.05），中药组优于对照组（<0.05）。结论清热化痰合剂联合振动排痰仪可改善痰热壅肺型 COPD 急性加重期患者的 TCM 证候评分、CAT 评分、血气分析、肺功能和炎症指标。
