Treacy A, Reynolds J, Kay E W, Leader M, Grace A
Department of Pathology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
Diagn Cytopathol. 2009 Apr;37(4):239-40. doi: 10.1002/dc.20993.
Liquid-based cytology (LBC) has replaced conventional smear assessment in many centers over recent years. In our laboratory this transfer took place in 1999. At that time we performed a split sample study comparing the conventional method of cervical smear evaluation with the ThinPrep system. This split sample study identified a dramatic improvement in specimen adequacy with LBC. While 11% of conventional preparations were reported as unsatisfactory and almost 9% were reported as suboptimal, evaluation of the same cases using LBC saw this combined figure reduced to 2.3%.
To evaluate whether this dramatic fall in unsatisfactory smears has been maintained with the use of LBC. The database for all smears reported for 2005 (100% LBC) was interrogated. The number of unsatisfactory reports was calculated. The reason for an unsatisfactory report was recorded for each case. The overall unsatisfactory rate was compared with that reported in the 1999 split sample study. A total of 41,312 smear tests were reported in 2005. 1,342 (3.25%) were reported as unsatisfactory. Our findings support the ongoing value of LBC in a routine cervical screening laboratory in terms of continuing to maintain a low rate of unsatisfactory smears.
近年来，液基细胞学检查（LBC）在许多中心已取代了传统涂片评估。在我们实验室，这一转变发生在1999年。当时我们进行了一项样本拆分研究，将宫颈涂片评估的传统方法与ThinPrep系统进行比较。这项样本拆分研究发现，LBC使样本充足率有了显著提高。传统涂片制备中有11%被报告为不满意，近9%被报告为次优，而对相同病例使用LBC进行评估时，这一合并数字降至2.3%。
评估使用LBC后，不满意涂片的这种显著下降是否得以维持。对2005年报告的所有涂片（100%为LBC）的数据库进行了查询。计算了不满意报告的数量。记录了每个病例不满意报告的原因。将总体不满意率与1999年样本拆分研究中报告的率进行比较。2005年共报告了41312次涂片检查。1342次（3.25%）被报告为不满意。我们的研究结果支持LBC在常规宫颈筛查实验室中的持续价值，即继续保持较低的不满意涂片率。
