Boutte C, Gaudin P, Grange L, Georgescu D, Besson G, Lagrange E
Unité de neurologie générale, pôle de neurologie et de psychiatrie, CHU de Grenoble, BP 217, 38043 Grenoble cedex 9, France.
Rev Neurol (Paris). 2009 May;165(5):460-5. doi: 10.1016/j.neurol.2008.11.012. Epub 2009 Feb 12.
Many studies had been performed in the last years to prove the usefulness of ultrasonographic measurements of the median nerve in the diagnosis of carpal tunnel syndrome (CTS). We wanted to determine its reliability and to compare this technology with electromyography (EMG) in ordinary diagnostic conditions.
The study involved 90 wrists with suspected CTS, 35 controlateral wrists and 52 control wrists. The diagnosis of CTS was confirmed in 81 cases by the hand symptom diagram and the Tinnel and Phalen sign. The EMG examination evaluated medianulnar sensory latency difference to the ring finger and wrist-to-palm sensory conduction velocity. For the ultrasound diagnosis, the cross sectional area of the median nerve at the level of the pisiform bone, was considered. The sensitivity and specificity of the two techniques was calculated.
Sensitive electroneurographic parameters showed a sensibility and specificity respectively of 79 and 80%. The cut-off point for ultrasound sensibility and specificity using ROC analysis was 11mm(2) for mean cross-sectional area. Sensitivity and specificity found in this way were 72% and 56%. Reliability was good with intra- and inter-reader intraclass correlation coefficients of 0.99, and interobserver coefficient of 0.88. Sonography found seven CTS among the 17 clinical CTS with normal electrophysiological findings. A statistically correlation was found between the cross-sectional section and the sensitive electrophysiologic parameters (r=0.43, p<0.001).
In our study, ultrasonographic diagnostic value are not as good as electrophysiological value, like found in recent literature, probably because of the composition of our group of patients which is including many causes of acroparesthesias. This can mean that in clinical practice, sonography is a complementary tool instead, for example in cases of equivocal EMG.
过去几年进行了许多研究,以证明超声测量正中神经在腕管综合征(CTS)诊断中的作用。我们想确定其可靠性,并在普通诊断条件下将该技术与肌电图(EMG)进行比较。
该研究纳入了90例疑似CTS的手腕、35例对侧手腕和52例对照手腕。通过手部症状图以及Tinnel征和Phalen征,81例确诊为CTS。肌电图检查评估了环指的正中神经-尺神经感觉潜伏期差异以及腕部至手掌的感觉传导速度。对于超声诊断,考虑了豌豆骨水平处正中神经的横截面积。计算了两种技术的敏感性和特异性。
敏感的神经电图参数显示敏感性和特异性分别为79%和80%。使用ROC分析得出的超声敏感性和特异性的截断点为平均横截面积11mm²。以此方式得出的敏感性和特异性分别为72%和56%。可靠性良好,读者内和读者间组内相关系数为0.99,观察者间系数为0.88。超声检查在17例电生理检查结果正常的临床CTS病例中发现了7例CTS。横截面积与敏感的电生理参数之间存在统计学相关性(r = 0.43,p < 0.001)。
在我们的研究中,超声诊断价值不如电生理价值,正如最近文献中所发现的那样,这可能是因为我们的患者群体构成包括多种肢端感觉异常的病因。这可能意味着在临床实践中,超声检查是一种辅助工具,例如在肌电图检查结果不明确的情况下。