Purwosunu Yuditiya, Sekizawa Akihiko, Okazaki Shiho, Farina Antonio, Wibowo Noroyono, Nakamura Masamitsu, Rizzo Nicola, Saito Hiroshi, Okai Takashi
Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Am J Obstet Gynecol. 2009 Apr;200(4):386.e1-7. doi: 10.1016/j.ajog.2008.11.035. Epub 2009 Feb 14.
The purpose of this study was to predict the occurrence of preeclampsia in a series of patients at gestational week 15-20 weeks, with the use of a panel of messenger RNA markers.
Data from 62 patients with preeclampsia who were asymptomatic at the time of blood testing and 310 control subjects were analyzed. Multivariable analysis was performed with discriminant analysis.
Univariable analysis identified vascular endothelial growth factor receptor 1 as the marker with the highest detection rate; placenta-specific 1 with the lowest. Mean estimated score for preeclampsia was 9.4 for control subjects and 72.5 for subjects who experienced preeclampsia. A receiver operating characteristic curve that was obtained with the estimated score for preeclampsia as a test variable yielded a detection rate of 84% (95% CI, 71.8-91.5) at a 5% false-positive rate with an area under the curve of 0.927 (P < .001). Again, detection rate and score for each patient for classification as preeclamptic correlated with severity.
A panel of messenger RNA is able to detect subjects who will experience preeclampsia.
本研究旨在利用一组信使核糖核酸标志物预测一系列孕15 - 20周患者子痫前期的发生情况。
分析了62例血液检测时无症状的子痫前期患者和310例对照受试者的数据。采用判别分析进行多变量分析。
单变量分析确定血管内皮生长因子受体1为检测率最高的标志物；胎盘特异性蛋白1检测率最低。对照受试者子痫前期的平均估计评分为9.4，子痫前期患者的平均估计评分为72.5。以子痫前期估计评分为检验变量绘制的受试者工作特征曲线在假阳性率为5%时检测率为84%（95%置信区间，71.8 - 91.5），曲线下面积为0.927（P < 0.001）。再次表明，每位患者子痫前期分类的检测率和评分与严重程度相关。
一组信使核糖核酸能够检测出将会发生子痫前期的受试者。
