Division of Rheumatology and Immunology, Department of Medicine, David Geffen Medical School at UCLA, Los Angeles, CA 90095, USA.
Semin Arthritis Rheum. 2010 Aug;40(1):89-94. doi: 10.1016/j.semarthrit.2008.11.006. Epub 2009 Feb 13.
To contrast and compare the spectrum of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) with rheumatoid arthritis (RA) using an illustrative case.
The relevant English literature of RS3PE was searched using the keywords "RS3PE" alone and in combination with terms such as neoplasia and rheumatic disease. Original and review articles were reviewed and the clinical setting was exemplified with a case report.
RS3PE initially was reported to represent a form of RA. However, RS3PE has clinical features that are different from both early- and late-onset RA, such as lack of bony erosions and rheumatoid factor. RS3PE is thought to involve vascular endothelial growth factor, suggesting an infectious etiology, generally has an excellent prognosis, and is associated with neoplasia not commonly seen in RA, and the RA associated human leukocyte antigen (HLA) DRB1 genotype is absent.
Based on the clinical, laboratory, suspected infectious etiology, genetic differences, and types of associated malignancies, RS3PE appears to be a distinct entity rather than a subset of RA.
通过一个实例说明和对比缓解性血清阴性对称性滑膜炎伴凹陷性水肿（RS3PE）与类风湿关节炎（RA）的光谱。
单独使用“RS3PE”和结合肿瘤及风湿性疾病等术语，搜索有关 RS3PE 的英文文献。综述原始和综述文章，并以病例报告举例说明临床情况。
RS3PE 最初被认为是 RA 的一种形式。然而，RS3PE 具有与早发性和迟发性 RA 不同的临床特征，例如缺乏骨侵蚀和类风湿因子。RS3PE 被认为与血管内皮生长因子有关，提示感染病因，通常预后良好，并且与 RA 中不常见的肿瘤有关，而 RA 相关的人类白细胞抗原（HLA）DRB1 基因型不存在。
根据临床、实验室、疑似感染病因、遗传差异和相关恶性肿瘤类型，RS3PE 似乎是一种独特的实体，而不是 RA 的一个子集。
