静脉注射免疫球蛋白在多发性硬化症中的治疗作用涉及趋化因子表达的调节。
Therapeutic activities of intravenous immunoglobulins in multiple sclerosis involve modulation of chemokine expression.
作者信息
Pigard Nadine, Elovaara Irina, Kuusisto Hanna, Paalavuo Raija, Dastidar Prasun, Zimmermann Klaus, Schwarz Hans-Peter, Reipert Birgit
机构信息
BMT-Research GmbH, Vienna, Austria.
出版信息
J Neuroimmunol. 2009 Apr 30;209(1-2):114-20. doi: 10.1016/j.jneuroim.2009.01.014. Epub 2009 Feb 13.
The objective of this study was to identify genes that are differentially expressed in peripheral T cells of patients with MS exacerbation receiving treatment with IVIG. Using microarray analysis, we identified 360 genes that were at least two-fold up- or down-regulated. The expression of four representative genes (PTGER4, CXCL5, IL11 and CASP2) was confirmed by quantitative PCR. Four of the differentially expressed genes encode chemokines (CXCL3, CXCL5, CCL13 and XCL2) that are involved in directing leukocyte migration. We suggest that the modulation of chemokine expression in peripheral T cells contributes to the beneficial activity of IVIG in patients with MS exacerbation.
本研究的目的是鉴定在接受静脉注射免疫球蛋白（IVIG）治疗的多发性硬化症（MS）病情加重患者外周T细胞中差异表达的基因。通过微阵列分析，我们鉴定出360个基因，其表达上调或下调至少两倍。通过定量PCR证实了四个代表性基因（PTGER4、CXCL5、IL11和CASP2）的表达。差异表达的基因中有四个编码趋化因子（CXCL3、CXCL5、CCL13和XCL2），它们参与引导白细胞迁移。我们认为，外周T细胞中趋化因子表达的调节有助于IVIG对MS病情加重患者的有益作用。
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