关于姐妹染色单体支架的偏手性。

On the handedness of the scaffolds of sister chromatids.

作者信息

Matioli G T

机构信息

USC School of Medicine, Los Angeles 90033.

出版信息

Med Hypotheses. 1991 May;35(1):52-8. doi: 10.1016/0306-9877(91)90082-a.

DOI:10.1016/0306-9877(91)90082-a

PMID:1921777

Abstract

We discuss a mechanical model for the mirror-symmetric inversion of the scaffold's helicity of replicated chromatids vis-a-vis that of their templates. The paper ends with comments on the orientability of certain genes and on the effects of such topologies upon (a)symmetric gene expression, in general. Our model and its generalizations apply only to the special subclass of 'coiled' chromatids whose statistical distribution in the genome of normal and of malignant cells is not known precisely.

摘要

我们讨论了一个关于复制染色单体与其模板相比，其螺旋度镜面对称反转的力学模型。本文最后评论了某些基因的可定向性，以及一般情况下这种拓扑结构对（非）对称基因表达的影响。我们的模型及其推广仅适用于“盘绕”染色单体的特殊子类，其在正常细胞和恶性细胞基因组中的统计分布尚不清楚。