利用差异基因表达研究溶组织内阿米巴的致病机制。
Using differential gene expression to study Entamoeba histolytica pathogenesis.
作者信息
Gilchrist Carol A, Petri William A
机构信息
Division of Infectious Diseases and International Health, Departments of Medicine, Microbiology and Pathology, University of Virginia, PO Box 801340, Charlottesville, VA 22908-1340, USA.
出版信息
Trends Parasitol. 2009 Mar;25(3):124-31. doi: 10.1016/j.pt.2008.12.007. Epub 2009 Feb 13.
Abstract
The release of the Entamoeba histolytica genome has facilitated the development of techniques to survey rapidly and to relate gene expression with biology. The association and potential contribution of differential gene expression to the life cycle and the virulence of this protozoan parasite of humans are reviewed here.
摘要
溶组织内阿米巴基因组的发布推动了快速检测技术的发展，并促进了基因表达与生物学之间的关联。本文综述了差异基因表达与这种人类原生动物寄生虫的生命周期及毒力之间的关联和潜在作用。
相似文献
1
Using differential gene expression to study Entamoeba histolytica pathogenesis.利用差异基因表达研究溶组织内阿米巴的致病机制。
Trends Parasitol. 2009 Mar;25(3):124-31. doi: 10.1016/j.pt.2008.12.007. Epub 2009 Feb 13.
2
New insights into Entamoeba histolytica pathogenesis.溶组织内阿米巴致病机制的新见解。
Curr Opin Infect Dis. 2008 Oct;21(5):489-94. doi: 10.1097/QCO.0b013e32830ce75f.
3
Host-Parasite interactions in Entamoeba histolytica and Entamoeba dispar: what have we learned from their genomes?溶组织内阿米巴和迪斯帕内阿米巴的寄生虫-宿主相互作用：从它们的基因组中我们了解到了什么？
Parasite Immunol. 2012 Feb-Mar;34(2-3):90-9. doi: 10.1111/j.1365-3024.2011.01325.x.
4
Regulation of virulence of Entamoeba histolytica.溶组织内阿米巴毒力的调控
Annu Rev Microbiol. 2014;68:493-520. doi: 10.1146/annurev-micro-091313-103550. Epub 2014 Jun 16.
5
Genomic DNA microarrays for Entamoeba histolytica: applications for use in expression profiling and strain genotyping.用于溶组织内阿米巴的基因组DNA微阵列：在表达谱分析和菌株基因分型中的应用。
Exp Parasitol. 2005 Jul;110(3):196-202. doi: 10.1016/j.exppara.2005.03.006. Epub 2005 Apr 8.
6
The knockdown of each component of the cysteine proteinase-adhesin complex of Entamoeba histolytica (EhCPADH) affects the expression of the other complex element as well as the in vitro and in vivo virulence.溶组织内阿米巴半胱氨酸蛋白酶-粘附素复合物（EhCPADH）各组分的敲低会影响其他复合物元件的表达以及体外和体内毒力。
Parasitology. 2016 Jan;143(1):50-9. doi: 10.1017/S003118201500147X. Epub 2015 Nov 2.
7
Identification of differentially expressed genes in virulent and nonvirulent Entamoeba species: potential implications for amebic pathogenesis.致病与非致病阿米巴物种中差异表达基因的鉴定：对阿米巴病发病机制的潜在影响
Infect Immun. 2006 Jan;74(1):340-51. doi: 10.1128/IAI.74.1.340-351.2006.
8
Entamoeba histolytica: a snapshot of current research and methods for genetic analysis.溶组织内阿米巴：当前研究和遗传分析方法概述。
Curr Opin Microbiol. 2012 Aug;15(4):469-75. doi: 10.1016/j.mib.2012.04.011. Epub 2012 Jun 2.
9
Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica.溶组织内阿米巴滋养体对胶原蛋白结合的基因组反应鉴定。
J Infect Dis. 2004 Aug 1;190(3):448-57. doi: 10.1086/422323. Epub 2004 Jul 2.
10
Virulence factors of Entamoeba histolytica.溶组织内阿米巴的致病因子。
Curr Opin Microbiol. 1999 Aug;2(4):433-7. doi: 10.1016/S1369-5274(99)80076-9.
引用本文的文献
1
Gene expression of axenically-isolated clinical Entamoeba histolytica strains and its impact on disease severity of amebiasis.临床分离的无共生 Entamoeba histolytica 株的基因表达及其对阿米巴病严重程度的影响。
PLoS Pathog. 2022 Sep 30;18(9):e1010880. doi: 10.1371/journal.ppat.1010880. eCollection 2022 Sep.
2
Comparison of hemolytic activity of the intermediate subunit of Entamoeba histolytica and Entamoeba dispar lectins.溶组织内阿米巴和迪斯帕内阿米巴凝集素中间亚基的溶血活性比较。
PLoS One. 2017 Jul 27;12(7):e0181864. doi: 10.1371/journal.pone.0181864. eCollection 2017.
3
The MAK16 gene of Entamoeba histolytica and its identification in isolates from patients.溶组织内阿米巴的MAK16基因及其在患者分离株中的鉴定。
Korean J Parasitol. 2014 Aug;52(4):429-33. doi: 10.3347/kjp.2014.52.4.429. Epub 2014 Aug 29.
4
Regulation of virulence of Entamoeba histolytica.溶组织内阿米巴毒力的调控
Annu Rev Microbiol. 2014;68:493-520. doi: 10.1146/annurev-micro-091313-103550. Epub 2014 Jun 16.
5
Peroxynitrite and peroxiredoxin in the pathogenesis of experimental amebic liver abscess.过氧亚硝酸盐和过氧化物酶在实验性阿米巴肝脓肿发病机制中的作用
Biomed Res Int. 2014;2014:324230. doi: 10.1155/2014/324230. Epub 2014 Apr 15.
6
Identification of the virulence landscape essential for Entamoeba histolytica invasion of the human colon.鉴定与溶组织内阿米巴感染人类结肠相关的毒力特征。
PLoS Pathog. 2013;9(12):e1003824. doi: 10.1371/journal.ppat.1003824. Epub 2013 Dec 19.
7
The genome and transcriptome of the enteric parasite Entamoeba invadens, a model for encystation.肠内寄生虫 Entamoeba invadens 的基因组和转录组，囊前期的模型。
Genome Biol. 2013 Jul 26;14(7):R77. doi: 10.1186/gb-2013-14-7-r77.
8
A Multilocus Sequence Typing System (MLST) reveals a high level of diversity and a genetic component to Entamoeba histolytica virulence.多位点序列分型系统（MLST）揭示了溶组织内阿米巴的高多样性和遗传组成与毒力相关。
BMC Microbiol. 2012 Jul 27;12:151. doi: 10.1186/1471-2180-12-151.
9
Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemokine activity towards human endothelial cells.溶组织内阿米巴赖氨酸 tRNA 合成酶含有细胞因子样结构域，对人内皮细胞具有趋化活性。
PLoS Negl Trop Dis. 2011 Nov;5(11):e1398. doi: 10.1371/journal.pntd.0001398. Epub 2011 Nov 29.
10
Host-Parasite interactions in Entamoeba histolytica and Entamoeba dispar: what have we learned from their genomes?溶组织内阿米巴和迪斯帕内阿米巴的寄生虫-宿主相互作用：从它们的基因组中我们了解到了什么？
Parasite Immunol. 2012 Feb-Mar;34(2-3):90-9. doi: 10.1111/j.1365-3024.2011.01325.x.
本文引用的文献
1
Recent insights into Entamoeba development: identification of transcriptional networks associated with stage conversion.近期对溶组织内阿米巴发育的见解：与阶段转换相关的转录网络的鉴定。
Int J Parasitol. 2009 Jan;39(1):41-7. doi: 10.1016/j.ijpara.2008.09.004. Epub 2008 Oct 4.
2
Targets of the Entamoeba histolytica transcription factor URE3-BP.溶组织内阿米巴转录因子 URE3-BP 的靶标。
PLoS Negl Trop Dis. 2008;2(8):e282. doi: 10.1371/journal.pntd.0000282. Epub 2008 Aug 27.
3
Entamoeba histolytica modulates a complex repertoire of novel genes in response to oxidative and nitrosative stresses: implications for amebic pathogenesis.溶组织内阿米巴对氧化应激和亚硝化应激反应时调控一系列复杂的新基因：对阿米巴病发病机制的影响
Cell Microbiol. 2009 Jan;11(1):51-69. doi: 10.1111/j.1462-5822.2008.01236.x. Epub 2008 Sep 5.
4
An Entamoeba cysteine peptidase specifically expressed during encystation.一种在包囊化过程中特异性表达的溶组织内阿米巴半胱氨酸蛋白酶。
Parasitol Int. 2008 Dec;57(4):521-4. doi: 10.1016/j.parint.2008.07.002. Epub 2008 Aug 5.
5
Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection.肠道感染期间诱导产生的溶组织内阿米巴高迁移率族框蛋白的特性分析。
Eukaryot Cell. 2008 Sep;7(9):1565-72. doi: 10.1128/EC.00123-08. Epub 2008 Jul 25.
6
EhMLBP is an essential constituent of the Entamoeba histolytica epigenetic machinery and a potential drug target.EhMLBP是溶组织内阿米巴表观遗传机制的重要组成部分，也是一个潜在的药物靶点。
Mol Microbiol. 2008 Jul;69(1):55-66. doi: 10.1111/j.1365-2958.2008.06258.x. Epub 2008 May 12.
7
Chemotaxis of Entamoeba histolytica towards the pro-inflammatory cytokine TNF is based on PI3K signalling, cytoskeleton reorganization and the Galactose/N-acetylgalactosamine lectin activity.溶组织内阿米巴对促炎细胞因子TNF的趋化作用基于磷脂酰肌醇-3激酶（PI3K）信号传导、细胞骨架重组和半乳糖/N-乙酰半乳糖胺凝集素活性。
Cell Microbiol. 2008 Aug;10(8):1676-86. doi: 10.1111/j.1462-5822.2008.01158.x. Epub 2008 Apr 16.
8
Tissue invasion by Entamoeba histolytica: evidence of genetic selection and/or DNA reorganization events in organ tropism.溶组织内阿米巴对组织的侵袭：器官趋向性中的遗传选择和/或 DNA 重组事件的证据。
PLoS Negl Trop Dis. 2008 Apr 9;2(4):e219. doi: 10.1371/journal.pntd.0000219.
9
Optimization of minuscule samples for use with cDNA microarrays.用于cDNA微阵列的微量样本优化
J Biochem Biophys Methods. 2008 Apr 24;70(6):1048-58. doi: 10.1016/j.jprot.2007.11.011. Epub 2007 Dec 23.
10
Trichostatin A regulates peroxiredoxin expression and virulence of the parasite Entamoeba histolytica.曲古抑菌素A调节溶组织内阿米巴原虫的过氧化物还原酶表达及毒力。
Mol Biochem Parasitol. 2008 Mar;158(1):82-94. doi: 10.1016/j.molbiopara.2007.11.014. Epub 2007 Dec 4.
Zotero 插件