Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
Parasite Immunol. 2012 Feb-Mar;34(2-3):90-9. doi: 10.1111/j.1365-3024.2011.01325.x.
Invasive amoebiasis caused by Entamoeba histolytica is a major global health problem. Virulence is a rare outcome of infection, occurring in fewer than 1 in 10 infections. Not all strains of the parasite are equally virulent, and understanding the mechanisms and causes of virulence is an important goal of Entamoeba research. The sequencing of the genome of E. histolytica and the related avirulent species Entamoeba dispar has allowed whole-genome-scale analyses of genetic divergence and differential gene expression to be undertaken. These studies have helped elucidate mechanisms of virulence and identified genes differentially expressed in virulent and avirulent parasites. Here, we review the current status of the E. histolytica and E. dispar genomes and the findings of a number of genome-scale studies comparing parasites of different virulence.
由溶组织内阿米巴引起的侵袭性阿米巴病是一个全球性的主要健康问题。溶组织内阿米巴的毒力是感染的罕见后果，不到 10 次感染中就会发生 1 次。并非寄生虫的所有菌株都具有同等的毒力，了解毒力的机制和原因是溶组织内阿米巴研究的一个重要目标。溶组织内阿米巴和相关的无致病力物种迪斯帕内阿米巴的基因组测序，使得可以对遗传分化和差异基因表达进行全基因组规模的分析。这些研究有助于阐明毒力机制，并确定在毒力和无致病力寄生虫中差异表达的基因。在这里，我们回顾了溶组织内阿米巴和迪斯帕内阿米巴基因组的现状，以及一些比较不同毒力寄生虫的全基因组研究的结果。
