Perry Stephanie M, Getz Charles L, Soslowsky Louis J
McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA.
J Shoulder Elbow Surg. 2009 Mar-Apr;18(2):296-304. doi: 10.1016/j.jse.2008.10.008.
This study examined the effect of multiple rotator cuff tendon tears on shoulder function in an animal model.
Forty-eight Sprague-Dawley rats were divided into uninjured control, supraspinatus tendon detachment, supraspinatus+infraspinatus tendon detachment, or supraspinatus+subscapularis tendon detachment groups. Functional assessment was determined through ambulatory parameters (paw and stride measures) and range of motion prior to tendon detachment and at various time points after tendon detachment.
Ambulatory parameters and total range of motion, representing measures of shoulder function, were significantly altered with rotator cuff tears. The addition of a second torn rotator cuff tendon (infraspinatus or subscapularis)had further detrimental effects on animal shoulder function compared to uninjured control.
This study demonstrated functional changes in a rat rotator cuff model. Many of the permanent functional changes were likely present because the required motion used for those actions can no longer be performed. For parameters that were transient, compensation with another limb or subsidence of pain may have occurred.
The findings in this study are consistent with the alterations in shoulder function observed with rotator cuff and other shoulder injuries in the human. Future studies using this model can begin to examine the root of the functional differences, whether it is pain, mechanical deficiency, or a combination of both, which cannot be fully studied clinically [corrected].
本研究在动物模型中考察了多条肩袖肌腱撕裂对肩部功能的影响。
将48只Sprague-Dawley大鼠分为未受伤对照组、冈上肌腱切断组、冈上肌+冈下肌腱切断组或冈上肌+肩胛下肌腱切断组。通过动态参数（爪部和步幅测量）以及肌腱切断前和切断后不同时间点的活动范围来进行功能评估。
代表肩部功能指标的动态参数和总活动范围因肩袖撕裂而发生显著改变。与未受伤对照组相比，第二条肩袖撕裂肌腱（冈下肌或肩胛下肌）的增加对动物肩部功能产生了进一步的不利影响。
本研究证明了大鼠肩袖模型中的功能变化。许多永久性的功能变化可能是因为那些动作所需的运动已无法再完成。对于短暂性的参数，可能发生了用另一肢体进行代偿或疼痛减轻的情况。
本研究结果与人类肩袖及其他肩部损伤所观察到的肩部功能改变一致。使用该模型的未来研究可以开始探究功能差异的根源，无论是疼痛、机械性缺陷，还是两者的结合，而这些在临床上无法进行充分研究[已修正]。
