Bain J R, Mackinnon S E, Hunter D A
Department of Surgery, University of Toronto, Ontario, Canada.
Plast Reconstr Surg. 1989 Jan;83(1):129-38. doi: 10.1097/00006534-198901000-00024.
Quantification of peripheral nerve regeneration in animal studies of nerve injury and repair by histologic, morphologic, and electrophysiologic parameters has been controversial because such studies may not necessarily correlate with actual nerve function. This study modifies the previously described sciatic functional index (SFI), tibial functional index (TFI), and peroneal functional index (PFI) based on multiple linear regression analysis of factors derived from measurements of walking tracks in rats with defined nerve injuries. The factors that contributed to these formulas were print-length factor (PLF), toe-spread factor (TSF), and intermediary toe-spread factor (ITF). It was shown that animals with selective nerve injuries gave walking tracks that were consistent, predictable, and based on known neuromuscular deficits. The new formula for sciatic functional index was compared with previously described indices. The sciatic functional index, tibial functional index, and peroneal functional index offer the peripheral nerve investigator a noninvasive quantitative assessment of hindlimb motor function in the rat with selective hindlimb nerve injury.
通过组织学、形态学和电生理参数对动物神经损伤与修复研究中的周围神经再生进行量化一直存在争议，因为此类研究不一定与实际神经功能相关。本研究基于对明确神经损伤大鼠行走轨迹测量所得因素的多元线性回归分析，对先前描述的坐骨神经功能指数（SFI）、胫神经功能指数（TFI）和腓总神经功能指数（PFI）进行了修正。构成这些公式的因素有步长因子（PLF）、趾展因子（TSF）和中间趾展因子（ITF）。结果表明，患有选择性神经损伤的动物给出的行走轨迹是一致的、可预测的，且基于已知的神经肌肉缺陷。将新的坐骨神经功能指数公式与先前描述的指数进行了比较。坐骨神经功能指数、胫神经功能指数和腓总神经功能指数为周围神经研究者提供了一种对患有选择性后肢神经损伤大鼠的后肢运动功能进行无创定量评估的方法。
