Qiu Yu-wen, Chen Cui-hua, Wang Li-ping, Sun Gui-qin, Su Gui-dong, Song Tian-rong, Li Jing, Li Ying-jia, Wang Chen, Zhong Mei
Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jan;29(1):23-5.
To explore the changes in lower limb deep vein diameters, blood flow velocity and blood biochemistry in full-term pregnant women for early diagnosis and treatment of prothrombotic state.
One hundred and twenty-eight full-term pregnant women at high risk of thrombosis (Group A), 61 healthy full-term pregnant women (Group B), and 42 healthy non-pregnant women (Group C) underwent high-resolution color Doppler ultrasound (CDU) for examining the deep veins of the lower limbs. The hematological indexes such as D-D, PLT, HGB, HCT, TT, APTT, PT, and FbgC were also observed in these 3 groups.
Compared to Group B, the women in group A showed significantly increased diameters of the common femoral veins (CFV) and left superficial femoral vein (SFV), HCT and DD, but with significantly decreased peak blood flow in the bilateral popliteal veins (POPV) (P<0.01) and increased left POPV diameter (P=0.034). Compared to those in group C, the diameters of the bilateral CFVs, SFVs, POPV, and posterior tibial veins (PTVs) were significantly increased, but the peak blood flow in the bilateral CFVs and POPVs were significantly reduced in groups A and B; the PLT, HGB, HCT, DD, TT, APTT, PT, and FbgC also showed significant changes in groups A and B (P<0.01).
The full-term pregnant women are at higher risk of prothrombotic state than non-pregnant women, and the full-term pregnant women with the high risk factors for thrombosis are more likely to have prothrombotic state than healthy full-term pregnant women. CDU examination of the lower limb deep veins can be of value in the diagnosis of prothrombotic state.
探讨足月孕妇下肢深静脉管径、血流速度及血液生化指标的变化，以便对血栓前状态进行早期诊断和治疗。
对128例血栓形成高危足月孕妇（A组）、61例健康足月孕妇（B组）和42例健康非孕妇女（C组）进行高分辨率彩色多普勒超声（CDU）检查下肢深静脉。同时观察这3组患者的D-二聚体（D-D）、血小板（PLT）、血红蛋白（HGB）、血细胞比容（HCT）、凝血酶时间（TT）、活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）及纤维蛋白原含量（FbgC）等血液学指标。
与B组相比，A组孕妇股总静脉（CFV）及左侧股浅静脉（SFV）管径、HCT及D-D显著增加，但双侧腘静脉（POPV）血流峰值显著降低（P<0.01），左侧POPV管径增大（P=0.034）。与C组相比，A组和B组双侧CFV、SFV、POPV及胫后静脉（PTV）管径均显著增宽，但双侧CFV和POPV血流峰值显著降低；A组和B组PLT、HGB、HCT、D-D、TT、APTT、PT及FbgC也有显著变化（P<0.01）。
足月孕妇血栓前状态的风险高于非孕妇女，有血栓形成高危因素的足月孕妇比健康足月孕妇更易发生血栓前状态。CDU检查下肢深静脉对血栓前状态的诊断有一定价值。
