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ClpXP degrades SsrA-tagged proteins in Streptococcus pneumoniae.
J Bacteriol. 2009 Apr;191(8):2894-8. doi: 10.1128/JB.01715-08. Epub 2009 Feb 13.
2
Turnover of endogenous SsrA-tagged proteins mediated by ATP-dependent proteases in Escherichia coli.
J Biol Chem. 2008 Aug 22;283(34):22918-29. doi: 10.1074/jbc.M801692200. Epub 2008 Jun 12.
4
Degradation of SsrA-tagged proteins in streptococci.
Microbiology (Reading). 2015 Apr;161(Pt 4):884-94. doi: 10.1099/mic.0.000048. Epub 2015 Feb 2.
5
An intrinsic degradation tag on the ClpA C-terminus regulates the balance of ClpAP complexes with different substrate specificity.
J Mol Biol. 2008 Dec 12;384(2):503-11. doi: 10.1016/j.jmb.2008.09.046. Epub 2008 Sep 26.
6
Cytoplasmic degradation of ssrA-tagged proteins.
Mol Microbiol. 2005 Sep;57(6):1750-61. doi: 10.1111/j.1365-2958.2005.04798.x.
7
Accessibility from the Cytoplasm Is Critical for ssrA Tag-Mediated Degradation of Integral Membrane Proteins by ClpXP Protease.
Biochemistry. 2018 Sep 25;57(38):5602-5608. doi: 10.1021/acs.biochem.8b00641. Epub 2018 Sep 12.
8
Evolution of the ssrA degradation tag in Mycoplasma: specificity switch to a different protease.
Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16113-8. doi: 10.1073/pnas.0808802105. Epub 2008 Oct 13.
9
Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis.
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10584-9. doi: 10.1073/pnas.191375298. Epub 2001 Sep 4.
10
The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery.
Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2219044120. doi: 10.1073/pnas.2219044120. Epub 2023 Feb 2.

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Recent Advances in the Structural Studies of the Proteolytic ClpP/ClpX Molecular Machine.
Biomolecules. 2025 Jul 29;15(8):1097. doi: 10.3390/biom15081097.
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Bacterial degrons in synthetic circuits.
Open Biol. 2022 Aug;12(8):220180. doi: 10.1098/rsob.220180. Epub 2022 Aug 17.
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Improving the Robustness of Engineered Bacteria to Nutrient Stress Using Programmed Proteolysis.
ACS Synth Biol. 2022 Mar 18;11(3):1049-1059. doi: 10.1021/acssynbio.1c00490. Epub 2022 Feb 17.
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Multiple domains of bacterial and human Lon proteases define substrate selectivity.
Emerg Microbes Infect. 2018 Aug 17;7(1):149. doi: 10.1038/s41426-018-0148-4.
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Identification of New Degrons in Reveals a Novel Strategy for Engineering Targeted, Controllable Proteolysis.
Front Microbiol. 2017 Dec 19;8:2572. doi: 10.3389/fmicb.2017.02572. eCollection 2017.
7
Degradation of SsrA-tagged proteins in streptococci.
Microbiology (Reading). 2015 Apr;161(Pt 4):884-94. doi: 10.1099/mic.0.000048. Epub 2015 Feb 2.
8
Competence in Streptococcus pneumoniae is a response to an increasing mutational burden.
PLoS One. 2013 Aug 13;8(8):e72613. doi: 10.1371/journal.pone.0072613. eCollection 2013.
9
Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities.
PLoS One. 2013;8(4):e60228. doi: 10.1371/journal.pone.0060228. Epub 2013 Apr 1.
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Competence in Streptococcus pneumoniae is regulated by the rate of ribosomal decoding errors.
mBio. 2011 Sep 20;2(5). doi: 10.1128/mBio.00071-11. Print 2011.

本文引用的文献

1
Evolution of the ssrA degradation tag in Mycoplasma: specificity switch to a different protease.
Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16113-8. doi: 10.1073/pnas.0808802105. Epub 2008 Oct 13.
3
Lon protease degrades transfer-messenger RNA-tagged proteins.
J Bacteriol. 2007 Sep;189(18):6564-71. doi: 10.1128/JB.00860-07. Epub 2007 Jul 6.
4
Direct and adaptor-mediated substrate recognition by an essential AAA+ protease.
Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6590-5. doi: 10.1073/pnas.0701776104. Epub 2007 Apr 9.
5
Development of genomic array footprinting for identification of conditionally essential genes in Streptococcus pneumoniae.
Appl Environ Microbiol. 2007 Mar;73(5):1514-24. doi: 10.1128/AEM.01900-06. Epub 2007 Jan 19.
6
Proteolytic adaptor for transfer-messenger RNA-tagged proteins from alpha-proteobacteria.
J Bacteriol. 2007 Jan;189(1):272-5. doi: 10.1128/JB.01387-06. Epub 2006 Nov 3.
7
Cytoplasmic degradation of ssrA-tagged proteins.
Mol Microbiol. 2005 Sep;57(6):1750-61. doi: 10.1111/j.1365-2958.2005.04798.x.
9
Essentiality of clpX, but not clpP, clpL, clpC, or clpE, in Streptococcus pneumoniae R6.
J Bacteriol. 2003 May;185(9):2961-6. doi: 10.1128/JB.185.9.2961-2966.2003.

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