Matthew C A, Moore M J
Orthopaedic Research Unit, University of Cambridge Clinical School, Addenbrookes Hospital, England.
Matrix. 1991 Aug;11(4):259-68. doi: 10.1016/s0934-8832(11)80233-7.
Alterations in collagen fibril diameter distribution were measured in rat extensor tendons subsequent to two-successive partial tenotomies, 30 days apart. Subsequent to surgery three areas were created. The primary lesion area, consisted of a regenerating window in the central half of the tissue. Secondary lesion areas consisted of strips at the lateral margin of the tissue, removed during the second operation. Between the lesion areas were the non-lesion areas consisting of tissue not removed during surgery. Tissue was examined 40, 60, 120 and 240 days after the initial operation. Within each group, primary and secondary lesion areas remained unimodal in collagen fibril diameter distribution throughout the period of the study. This distribution was initially unimodal in the non-lesion areas but became multimodal by 240 days postoperatively. Both the primary lesion area and non-lesion areas exhibited an increase in frequency of small diameter fibrils between 40 and 60 days postoperatively. It is suggested that all observations may be related to the level of applied stress.
在间隔30天进行的两次连续部分肌腱切断术后，测量大鼠伸肌腱中胶原纤维直径分布的变化。手术后创建了三个区域。原发性损伤区域，由组织中央一半的再生窗口组成。继发性损伤区域由组织外侧边缘的条带组成，在第二次手术中切除。损伤区域之间是非损伤区域，由手术期间未切除的组织组成。在初次手术后40、60、120和240天检查组织。在每组中，原发性和继发性损伤区域在整个研究期间的胶原纤维直径分布保持单峰。这种分布在非损伤区域最初是单峰的，但在术后240天变为多峰。原发性损伤区域和非损伤区域在术后40至60天之间均表现出小直径纤维频率的增加。有人认为，所有观察结果可能与施加的应力水平有关。
