Matthew C, Moore M J, Campbell L
Department of Anatomy, Marischal College, Aberdeen University, Scotland.
J Hand Surg Br. 1987 Oct;12(3):313-20. doi: 10.1016/0266-7681_87_90180-x.
A study was made of collagen fibril populations in healing tendon using a window lesion in rat extensor tendon. Two environments were thus created. One (the lesion area) where stress levels were reduced; the other (the non-lesion area) where stress levels were increased. In both areas a population of small diameter (less than 50nm) collagen fibrils were synthesized. Lesion area fibrils increased their diameter only slowly. Non-lesion area fibrils added to a population which increased its diameter distribution comparatively rapidly. It is suggested that in the lesion area fibrils were synthesized in response to tissue damage and low levels of stress. These may be of type III collagen. In the non-lesion area fibrils were synthesized in response to raised levels of stress. These may be of type I collagen. Implications of these events, especially as they might relate to gap formation in flexor tendon surgery are discussed.
利用大鼠伸肌腱的窗口损伤，对愈合肌腱中的胶原纤维群体进行了研究。由此创造了两种环境。一种（损伤区域）应力水平降低；另一种（非损伤区域）应力水平升高。在这两个区域都合成了小直径（小于50纳米）的胶原纤维群体。损伤区域的纤维直径增加缓慢。非损伤区域的纤维加入到一个群体中，该群体的直径分布相对较快地增加。有人认为，在损伤区域，纤维是因组织损伤和低应力水平而合成的。这些可能是III型胶原。在非损伤区域，纤维是因应力水平升高而合成的。这些可能是I型胶原。讨论了这些事件的意义，特别是它们可能与屈肌腱手术中的间隙形成有关。
