Ziora K, Ziora D, Oswiecimska J, Roczniak W, Machura E, Dworniczak S, Tomalak W, Dyduch A
Department of Pediatrics and Endocrinology, Silesian University of Medicine, Zabrze, Poland.
J Physiol Pharmacol. 2008 Dec;59 Suppl 6:801-7.
Repercussions of obesity on the lung function have been widely studied. The effect of serious malnutrition is less well known. The aim of study was to determine spirometric parameters in 102 malnourished girls with anorexia nervosa. Among these patients, only 71 aged 12-18 years (mean 15.6), mean BMI 15.8 kg/m(2), met the ATS/ERS forced expiratory maneuver criteria for spirometry. The most frequently observed abnormalities were: decreased IC seen in 33 (46%) girls and decreased PEF in 45 (63%) patients. Maximum voluntary ventilation was within the normal range in all but 2 subjects. Diminished values of FEV(1), FVC, FEV(1)/FVC, MEF(50) were observed in 10 (14%), 13 (18%), 3 (4%), and 3 (4%) patients, respectively. We found strong positive correlations between weight and absolute values of the examined parameters. We assume that spirometric abnormalities in anorexia are probably a result of respiratory muscle weakness and body mass loss.
肥胖对肺功能的影响已得到广泛研究。严重营养不良的影响则鲜为人知。本研究的目的是测定102名患有神经性厌食症的营养不良女孩的肺功能参数。在这些患者中，只有71名年龄在12 - 18岁（平均15.6岁），平均体重指数为15.8 kg/m²，符合美国胸科学会/欧洲呼吸学会肺功能测定用力呼气动作标准。最常观察到的异常情况为：33名（46%）女孩的吸气量降低，45名（63%）患者的呼气峰值流速降低。除2名受试者外，所有受试者的最大自主通气量均在正常范围内。分别有10名（14%）、13名（18%）、3名（4%）和3名（4%）患者的第一秒用力呼气容积、用力肺活量、第一秒用力呼气容积/用力肺活量、50%最大呼气流量值降低。我们发现体重与所检测参数的绝对值之间存在强正相关。我们认为神经性厌食症患者的肺功能异常可能是呼吸肌无力和体重减轻的结果。
