Zhang Yuanchao, Yu Chunshui, Zhou Yuan, Li Kuncheng, Li Chong, Jiang Tianzi
Department of Mathematics, Zhejiang University, Hangzhou, PR China.
Neuroreport. 2009 Mar 4;20(4):378-80. doi: 10.1097/WNR.0b013e3283249b34.
Structural and functional abnormalities have been extensively reported in major depressive disorder, but possible changes in cortical folding have not yet been explored in this disorder. This study investigated this issue in major depressive disorder using the local gyrification index. High-resolution magnetic resonance imaging was performed in 18 patients with first-episode major depressive disorder and 18 age-matched and sex-matched healthy individuals. The local gyrification index was applied to detect brain areas with abnormal cortical folding in major depressive disorder. Compared with healthy participants, patients with major depressive disorder showed significantly decreased local gyrification index in the bilateral mid-posterior cingulate, insula, and orbital frontal cortices, the left anterior cingulate cortex, and the right temporal operculum.
在重度抑郁症中，结构和功能异常已有广泛报道，但该疾病中皮质折叠的可能变化尚未得到研究。本研究使用局部脑回指数对重度抑郁症的这一问题进行了调查。对18例首发重度抑郁症患者和18名年龄及性别匹配的健康个体进行了高分辨率磁共振成像。应用局部脑回指数来检测重度抑郁症中皮质折叠异常的脑区。与健康参与者相比，重度抑郁症患者在双侧中后扣带回、岛叶和眶额皮质、左侧前扣带回皮质以及右侧颞叶岛盖的局部脑回指数显著降低。
