Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Pediatr Res. 2009 May;65(5 Pt 2):26R-31R. doi: 10.1203/PDR.0b013e31819e76c7.
Regulatory T cells and T helper 17 cells are two recently described lymphocyte subsets with opposing actions. In this review, we discuss the mechanisms that promote development of these cells from common precursors and the specific factors that impact their cell numbers and function. Altered regulation of this key developmental checkpoint may contribute to the pathophysiology of autoimmune diseases by tipping the balance toward inflammation. We also present recent findings that suggest how the equilibrium between regulatory T cells and proinflammatory T helper subsets might be pharmacologically restored for therapeutic benefit.
调节性 T 细胞和辅助性 T 细胞 17 细胞是最近描述的具有相反作用的两种淋巴细胞亚群。在这篇综述中，我们讨论了促进这些细胞从共同前体发育的机制，以及影响其细胞数量和功能的特定因素。这个关键发育检查点的调节异常可能通过向炎症倾斜来导致自身免疫性疾病的病理生理学。我们还提出了最近的发现，表明调节性 T 细胞和促炎辅助性 T 细胞亚群之间的平衡如何可能通过药理学恢复来获得治疗益处。
