Wenzek Christina, Siemes Devon, Hönes G Sebastian, Pastille Eva, Härting Nina, Kaiser Frank, Moeller Lars C, Engel Daniel R, Westendorf Astrid M, Führer Dagmar
Department of Endocrinology, Diabetology and Metabolism, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Institute for Experimental Immunology and Imaging, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
iScience. 2024 Jul 19;27(8):110547. doi: 10.1016/j.isci.2024.110547. eCollection 2024 Aug 16.
The immune system has emerged as an important target of thyroid hormones (THs); however, the role of TH in T cells has so far remained elusive. In this study, we assessed the effect of TH receptor α (TRα) signaling on activation and function of T cells. Our findings show that lack of canonical TRα action not only increased the frequency of regulatory T cells (Treg) but propelled an activated and migratory Treg phenotype and nuclear factor κB (NF-κB) activation in Treg. Conversely, canonical TRα action reduced activation of the NF-κB pathway previously shown to play a pivotal role in Treg differentiation and function. Taken together, our findings demonstrate that TRα impacts T cell differentiation and phenotype. Given the well-known interaction of inflammation, immune responses, and TH axis in e.g., severe illness, altered TH-TRα signaling may have an important role in regulating T cell responses during disease.
免疫系统已成为甲状腺激素（THs）的一个重要靶点；然而，TH在T细胞中的作用迄今仍不清楚。在本研究中，我们评估了甲状腺激素受体α（TRα）信号传导对T细胞活化和功能的影响。我们的研究结果表明，缺乏典型的TRα作用不仅增加了调节性T细胞（Treg）的频率，还推动了Treg的活化和迁移表型以及核因子κB（NF-κB）的活化。相反，典型的TRα作用降低了先前显示在Treg分化和功能中起关键作用的NF-κB途径的活化。综上所述，我们的研究结果表明TRα影响T细胞分化和表型。鉴于炎症、免疫反应和TH轴在例如严重疾病中的众所周知的相互作用，改变的TH-TRα信号传导可能在疾病期间调节T细胞反应中起重要作用。
