Rossi R, Bruscino N, Ricceri F, Grazzini M, Dindelli M, Lotti T
Cluster Dermatologic Department II, University of Florence School of Medicine, Florence, Italy.
G Ital Dermatol Venereol. 2009 Feb;144(1):79-83.
Photodynamic therapy (ALA/MAL-PDT) is indicated for the treatment of actinic keratoses, for superficial, nodular basal cell carcinoma and for Bowen's disease; there is evidence that PDT can be active also against bacteria, viruses and fungi. The new indications for PDT include many types of viral skin infections human papilloma virus (HPV)-related as verrucae of feet and hands, Condylomata acuminata, periungueal warts, epidermodysplasia verruciformis, but also viral skin lesions non HPV related as molluscum contagiosum and herpes simplex can be successfully treated. The use of PDT in HPV infections is due to its anti-inflammatory and antiproliferative skills: in the lesions treated there is a release of cytotoxic radicals which damage keratinocytes infected by HPV, inducing their selective apoptosis and necrosis. The PDT application in this field of lesions is safe and successful; in comparison with the other techniques it has less side-effects and less recurrences, but the most important property is that it is not-invasive: it means a reduced risk of infections and excellent cosmetic results.
光动力疗法（ALA/MAL-PDT）适用于治疗光化性角化病、浅表性结节性基底细胞癌和鲍温病；有证据表明，光动力疗法对细菌、病毒和真菌也有作用。光动力疗法的新适应症包括多种与人类乳头瘤病毒（HPV）相关的病毒性皮肤感染，如手足疣、尖锐湿疣、甲周疣、疣状表皮发育不良，也包括与HPV无关的病毒性皮肤病变，如传染性软疣和单纯疱疹，都可以成功治疗。光动力疗法用于HPV感染是因其具有抗炎和抗增殖作用：在治疗的病变部位会释放细胞毒性自由基，这些自由基会损伤被HPV感染的角质形成细胞，诱导其选择性凋亡和坏死。光动力疗法在该病变领域的应用是安全且成功的；与其他技术相比，它的副作用更少、复发率更低，但最重要的特性是它是非侵入性的：这意味着感染风险降低且美容效果极佳。
