Patskovsky S, Vallieres M, Maisonneuve M, Song In-Hyouk, Meunier M, Kabashin A V
Engineering Physics Department, Ecole Polytechnique de Montréal, C. P. 6079, succ. Centre-Ville, Montréal (Québec), Canada, H3C 3A7.
Opt Express. 2009 Feb 16;17(4):2255-63. doi: 10.1364/oe.17.002255.
This work is related to the development of phase-sensitive methodologies in Surface Plasmon Resonance (SPR) biosensing. We take advantage of a specific angular dependence of phase of light, reflected under SPR geometry, on parameters of the SPR-supporting metal, and propose a polarimetry-based methodology to easily determine the optimal calibration zero point, corresponding to the maximal phase sensitivity. The proposed methodology can significantly facilitate the calibration of the system in field and multi-channel sensing, broaden the dynamic range, as well as contribute to the development of feedback loops.
这项工作与表面等离子体共振（SPR）生物传感中相敏方法的发展有关。我们利用在SPR几何结构下反射的光的相位对支持SPR的金属参数的特定角度依赖性，提出了一种基于偏振测量的方法，以轻松确定对应于最大相位灵敏度的最佳校准零点。所提出的方法可以显著促进现场和多通道传感系统的校准，拓宽动态范围，并有助于反馈回路的发展。
