Stejskal David, Karpisek Milan, Hanulova Zuzana, Svestak Marek
Department of Laboratory Medicine & Internal Department, Sternberk Hospital, Jivavska 20, Sternberk, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008 Dec;152(2):217-21. doi: 10.5507/bp.2008.033.
Chemerin is a novel adipokine that has been suggested to play an important role in the pathogenesis of the metabolic syndrome. The aim of our study was to evaluate serum chemerin as a marker of the metabolic syndrome and to assess its predictive accuracy in a Caucasian population.
The study was designed as a cross-sectional study. Anthropometric measurements and serum analyses were done for Body Mass Index, waist circumference, chemerin, insulin, triacylglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, uric acid, and glucose in 55 non-obese healthy subjects and 181 subjects at risk for the metabolic syndrome. ROC curves were determined and the Chi-squared test was used to analyse the data.
Compared with healthy controls, subjects with suspected metabolic syndrome had significantly higher chemerin serum levels (medians: 266.0 vs.192.5 microg/l; P < 0.01). After further chemerin adjustment, the difference between the subgroups persisted. Chemerin serum levels correlated with age (r = 0.23), serum glucose (r = 0.23), HDL-cholesterol (r = -0.19), triacylglycerides (r = 0.22), systolic and diastolic blood pressure (r = 0.40; r = 0.24) and the number of metabolic syndrome risk factors (r = 0.47). At a serum chemerin cut-off level of 240 microg/l, the presence of the metabolic syndrome was diagnosed with 75 % sensitivity and 67 % specificity.
In conclusion, serum chemerin levels are associated with the characteristics of the metabolic syndrome and could be an independent marker of this disorder in a Caucasian population.
chemerin是一种新型脂肪因子，已被认为在代谢综合征的发病机制中起重要作用。我们研究的目的是评估血清chemerin作为代谢综合征的标志物，并评估其在白种人群中的预测准确性。
本研究设计为横断面研究。对55名非肥胖健康受试者和181名有代谢综合征风险的受试者进行了人体测量和血清分析，检测指标包括体重指数、腰围、chemerin、胰岛素、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、尿酸和血糖。绘制ROC曲线并使用卡方检验分析数据。
与健康对照组相比，疑似代谢综合征的受试者血清chemerin水平显著更高（中位数：266.0对192.5微克/升；P<0.01）。在进一步调整chemerin后，亚组间差异仍然存在。血清chemerin水平与年龄（r=0.23）、血清葡萄糖（r=0.23）、高密度脂蛋白胆固醇（r=-0.19）、甘油三酯（r=0.22）、收缩压和舒张压（r=0.40；r=0.24）以及代谢综合征风险因素数量（r=0.47）相关。血清chemerin临界值水平为240微克/升时，诊断代谢综合征的敏感性为75%，特异性为67%。
总之，血清chemerin水平与代谢综合征的特征相关，可能是白种人群中该疾病的一个独立标志物。
