脂肪组织分泌蛋白、饮食行为与肥胖之间的相互作用。
Interplay between adipose tissue secreted proteins, eating behavior and obesity.
机构信息
Department of Medicine III, Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, Liebigstr. 18, 04103, Leipzig, Germany.
Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich at the University of Leipzig and the University of Leipzig Medical Center, Leipzig, Germany.
出版信息
Eur J Nutr. 2022 Mar;61(2):885-899. doi: 10.1007/s00394-021-02687-w. Epub 2021 Oct 12.
PURPOSE
Adipokines may play an important role in the complex etiology of human obesity and its metabolic complications. Here, we analyzed the relationship between 15 adipokines, eating behavior and body-mass index (BMI).
METHODS
The study included 557 participants of the Sorbs (62.1% women, 37.9% men) and 3101 participants of the population-based LIFE-Adult cohorts (53.4% women, 46.4% men) who completed the German version of the Three-Factor-Eating Questionnaire to assess the eating behavior types cognitive restraint, disinhibition and hunger. Serum levels of 15 adipokines, including adiponectin, adipocyte fatty acid-binding protein (AFABP), angiopoietin-related growth factor (AGF), chemerin, fibroblast growth factor (FGF)-19, FGF-21, FGF-23, insulin-like growth factor (IGF)-1, interleukin (IL) 10, irisin, progranulin, vaspin, pro-neurotensin (pro-NT), pro-enkephalin (PENK) and leptin were measured. Based on significant correlations between several adipokines with different eating behavior items and BMI, we conducted mediation analyses, considering the eating behavior items as potential mediation variable towards BMI.
RESULTS
Here, we found that the positive association between chemerin, AFABP or leptin and BMI in Sorbian women was mediated by higher restraint or disinhibited eating, respectively. Additionally, in Sorbian women, the negative relation between IGF-1 and BMI was mediated by higher disinhibition and the positive link between AGF and BMI by lower disinhibition. In Sorbian men, the negative relationship between PENK and BMI was mediated by lower disinhibition and hunger, whereas the negative relation between IGF-1 and BMI was mediated by higher hunger. In the LIFE-Adult women´s cohort, associations between chemerin and BMI were mediated by decreased hunger or disinhibition, respectively, whereas relations between PENK and BMI were fully mediated by decreased disinhibition.
CONCLUSION
Our study suggests that adipokines such as PENK, IGF-1, chemerin, AGF, AFABP and leptin might affect the development of obesity by directly modifying individual eating behavior. Given the observational nature of the study, future experimental or mechanistic work is warranted.
目的
脂肪因子可能在人类肥胖及其代谢并发症的复杂病因中发挥重要作用。在这里，我们分析了 15 种脂肪因子、饮食行为与体重指数（BMI）之间的关系。
方法
该研究纳入了 Sorbs 人群（62.1%为女性，37.9%为男性）中的 557 名参与者和基于人群的 LIFE-Adult 队列（53.4%为女性，46.4%为男性）中的 3101 名参与者，他们完成了德国版三因素饮食问卷，以评估认知抑制、去抑制和饥饿这三种饮食行为类型。检测了 15 种脂肪因子（包括脂联素、脂肪细胞脂肪酸结合蛋白（AFABP）、血管生成素相关生长因子（AGF）、趋化素、成纤维细胞生长因子（FGF）-19、FGF-21、FGF-23、胰岛素样生长因子（IGF）-1、白细胞介素（IL）-10、鸢尾素、颗粒蛋白前体、内脏脂肪素、前神经降压素（pro-NT）、前啡肽（PENK）和瘦素）的血清水平。基于几种脂肪因子与不同饮食行为项目以及 BMI 之间存在显著相关性，我们进行了中介分析，将饮食行为项目视为 BMI 的潜在中介变量。
结果
我们发现，Sorbs 女性中趋化素、AFABP 或瘦素与 BMI 之间的正相关关系，分别由较高的抑制或去抑制饮食行为介导。此外，在 Sorbs 女性中，IGF-1 与 BMI 之间的负相关关系由较高的去抑制行为介导，而 AGF 与 BMI 之间的正相关关系由较低的去抑制行为介导。在 Sorbs 男性中，PENK 与 BMI 之间的负相关关系由较低的去抑制和饥饿行为介导，而 IGF-1 与 BMI 之间的负相关关系由较高的饥饿行为介导。在 LIFE-Adult 女性队列中，趋化素与 BMI 之间的关系由饥饿或去抑制减少介导，而 PENK 与 BMI 之间的关系则完全由去抑制减少介导。
结论
我们的研究表明，脂肪因子如 PENK、IGF-1、趋化素、AGF、AFABP 和瘦素可能通过直接改变个体的饮食行为来影响肥胖的发生。鉴于该研究的观察性质，未来需要进行实验或机制研究。
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