Xin Xiu-Lan, Ma Xiao-Chi, Zhang Bao-Jing, Su Dong-Hai, Wu Zhi-Ming, Wang Xiao-Jie, Li Xiao-Yan, Yuan Qi-Peng
Key Laboratory of Bioprocess of Beijing, Beijing University of Chemical Technology, Beijing, China.
J Asian Nat Prod Res. 2009;11(2):187-91. doi: 10.1080/10286020802619280.
The biotransformation of dehydroandrographolide (1) by Cunninghamella elegans was performed and four transformed products were obtained. Based on their extensive spectral data, the structures of these metabolites were identified as 3-oxo-dehydroandrographolide (2), 3-oxo-2beta-hydroxy-dehydroandrographolide (3), 3-oxo-8beta,17alpha-epoxydehydroandrographolide (4), 3,19-dihydroxy-7,11,13-ent-labdatrien-15,16-olide (5), respectively. Among them, products 3-5 are new compounds.
采用雅致小克银汉霉对穿心莲内酯（1）进行生物转化，得到了4个转化产物。根据它们丰富的光谱数据，将这些代谢产物的结构分别鉴定为3-氧代-穿心莲内酯（2）、3-氧代-2β-羟基-穿心莲内酯（3）、3-氧代-8β,17α-环氧穿心莲内酯（4）、3,19-二羟基-7,11,13-对映-赖百当三烯-15,16-内酯（5）。其中，产物3-5为新化合物。
