Xin Xiu-Lan, Deng Sha, Zhang Bao-Jing, Huang Shan-Shan, Tian Yan, Ma Xiao-Chi, An Lei, Shu Xiao-Hong, Yao Ji-Hong, Cui Xun
Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing 100029, China.
Nat Prod Commun. 2011 Jun;6(6):781-4.
Biotransformation of deoxyandrographolide (1) by Alternaria alternata AS 3.4578 gave five derivatives identified by spectral methods including 2D NMR as the known dehydroandrographolide (2) and 9beta-hydroxy-dehydroandrographolide (3) and the new compounds 9beta-hydroxy-deoxyandrographolide (4), 3alpha,17,19-trihydroxy-8,13-ent-labdadien-15,16-olide (5) and 3-oxo-9beta-hydroxy-deoxyandrographolide (6).
链格孢菌AS 3.4578对脱氧穿心莲内酯（1）进行生物转化得到了5种衍生物，通过包括二维核磁共振在内的光谱方法鉴定为已知的脱水穿心莲内酯（2）和9β-羟基-脱水穿心莲内酯（3），以及新化合物9β-羟基-脱氧穿心莲内酯（4）、3α,17,19-三羟基-8,13-对映-贝壳杉二烯-15,16-内酯（5）和3-氧代-9β-羟基-脱氧穿心莲内酯（6）。
