Xin Xiu-Lan, Cui Xun, Wang Changyuan, Zhang Bao-Jing, Ma Xiao-Chi, Huang Shan-Shan, Deng Sha, Tian Yan, Zhang Hou-Li, Yang Mei-Hua
Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing, China.
J Asian Nat Prod Res. 2011 Apr;13(4):350-5. doi: 10.1080/10286020.2011.558009.
Biotransformation of deoxyandrographolide (1) by Fusarium graminearum AS 3.4598 was investigated in this paper. And five transformed products of 1 by F. graminearum AS 3.4598 were obtained. Their chemical structures were characterized as 3-oxo-8α,17β-epoxy-14-deoxyandrographolide (2), 3-oxo-14-deoxyandrographolide (3), 3-oxo-17,19-dihydroxyl-8,13-ent-labdadien-15,16-olide (4), 1β-hydroxyl-14-deoxyandrographolide (5), and 7β-hydroxyl-14-deoxyandrographolide (6) by spectral methods including 2D NMR. Among them, products 2, 4, and 5 are new.
本文研究了禾谷镰刀菌AS 3.4598对脱氧穿心莲内酯（1）的生物转化。通过禾谷镰刀菌AS 3.4598得到了1的5种转化产物。通过二维核磁共振等光谱方法对其化学结构进行表征，分别为3-氧代-8α,17β-环氧-14-脱氧穿心莲内酯（2）、3-氧代-14-脱氧穿心莲内酯（3）、3-氧代-17,19-二羟基-8,13-反式-赖百当二烯-15,16-内酯（4）、1β-羟基-14-脱氧穿心莲内酯（5）和7β-羟基-14-脱氧穿心莲内酯（6）。其中，产物2、4和5为新化合物。
