Hansen Steen Honoré
Department of Pharmaceutics and Analytical Chemsitry, Faculty of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
J Sep Sci. 2009 Mar;32(5-6):825-34. doi: 10.1002/jssc.200800623.
In present time the use or misuse of morphine and its derivatives are monitored by assaying the presence of the drug and its metabolites in biofluids. In the present review, focus is placed on the sample preparation and on the separation techniques used in the current best practices of bioanalysis of morphine and its major metabolites. However, as methods for testing the misuse of heroin, a morphine derivative, often involve bioanalytical methods that cover a number of other illicit drug substances, such methods are also included in the review. Furthermore, the review also includes bioanalysis in a broader perspective as analysis of plant materials, cell cultures and environmental samples. The review is not intended to cover all publications that include bioanalysis of morphine but is more to be considered a view into the current best practices of bioanalysis of morphine, its metabolites and other related substances.
目前，通过检测生物流体中药物及其代谢物的存在来监测吗啡及其衍生物的使用或滥用情况。在本综述中，重点关注样品制备以及吗啡及其主要代谢物生物分析当前最佳实践中所使用的分离技术。然而，由于检测吗啡衍生物海洛因滥用情况的方法通常涉及涵盖许多其他非法药物物质的生物分析方法，因此这些方法也包含在本综述中。此外，本综述还从更广泛的角度纳入生物分析，如植物材料、细胞培养物和环境样品的分析。本综述并非旨在涵盖所有包含吗啡生物分析的出版物，而更应被视为对吗啡、其代谢物及其他相关物质生物分析当前最佳实践的一种审视。
