Bodnar Brian S, Vogt Paul F
Process Development Services, SiGNa Chemistry, Inc., 1 Deer Park Drive, Suite C, Monmouth Junction, New Jersey 08852, USA.
J Org Chem. 2009 Mar 20;74(6):2598-600. doi: 10.1021/jo802778z.
Significantly improved Bouveault-Blanc conditions for ester reduction have been developed using sodium in silica gel (Na-SG), a free-flowing powder that can be easily handled in the open atmosphere. Primary alcohols were prepared in excellent yield from a variety of aliphatic esters under mild reaction conditions. The chemistry presented here is far safer than the classic Bouveault-Blanc reduction and is competitive with more modern hydride reduction methods.
利用硅胶钠（Na-SG）开发出了显著改进的用于酯还原的布沃-布朗克反应条件，硅胶钠是一种可自由流动的粉末，在开放大气中易于操作。在温和的反应条件下，由各种脂肪族酯制备伯醇的产率极高。此处介绍的化学方法比经典的布沃-布朗克还原法安全得多，并且与更现代的氢化物还原方法具有竞争力。
