Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA.
J Org Chem. 2013 Apr 19;78(8):4123-31. doi: 10.1021/jo400488q. Epub 2013 Apr 9.
A method has been developed for the Pd-catalyzed synthesis of α-(hetero)aryl esters and amides through a Suzuki-Miyaura cross-coupling reaction. This method avoids the use of strong base, does not necessitate inert or low temperature formation of reagents, and does not require the use of a large excess of organometallic reagent. Utilization of organotrifluoroborate salts as nucleophilic partners allows a variety of functional groups and heterocyclic compounds to be tolerated.
已经开发出一种通过钯催化的 Suzuki-Miyaura 交叉偶联反应合成 α-（杂）芳基酯和酰胺的方法。该方法避免了强碱的使用，不需要在惰性或低温下形成试剂，也不需要使用大量的有机金属试剂。利用有机三氟硼酸盐作为亲核试剂可以容忍各种官能团和杂环化合物。
