Department of Pathology, Johns Hopkins University School of Medicine, Maryland, USA.
J Infect Dis. 2009 Apr 1;199(7):945-9. doi: 10.1086/597074.
Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878 .).
在非洲，男性感染单纯疱疹病毒 2 型（HSV-2）的风险因素知之甚少。在乌干达拉凯的一项试验中，对 6396 名年龄在 15-49 岁的男性进行了血清学检测，以评估他们是否存在 HSV-2、人类免疫缺陷病毒（HIV）和梅毒感染。HSV-2 感染的患病率为 33.76%，发病率为每 100 人年 4.90 例。HSV-2 的发病率随着性伴饮酒而增加（调整后的发病率比[adjIRR]，1.92 [95%置信区间{CI}，1.46-2.53]），随着坚持使用安全套（adjIRR，0.56 [95% CI，0.36-0.89]）和男性包皮环切（adjIRR，0.70 [95% CI，0.55-0.91]）而降低，与入组时的 HIV 状态无关。对可改变的行为变化进行教育可能会降低 HSV-2 的感染率。（临床试验标识符：NCT00425984 和 NCT00124878）。
