乌干达拉凯地区男性包皮环切伤口处的2型单纯疱疹病毒脱落情况[已修正]
Herpes Simplex [corrected] Virus Type 2 Shedding From Male Circumcision Wounds in Rakai, Uganda.
作者信息
Grabowski Mary K, Kigozi Godfrey, Gray Ronald H, Armour Benjamin, Manucci Jordyn, Serwadda David, Redd Andrew D, Nalugoda Fred, Patel Eshan U, Wawer Maria J, Quinn Thomas C, Tobian Aaron A R
机构信息
Department of Epidemiology, Bloomberg School of Public Health.
Rakai Health Sciences Program, Entebbe.
出版信息
J Infect Dis. 2015 Nov 15;212(10):1613-7. doi: 10.1093/infdis/jiv259. Epub 2015 May 5.
A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use.
对176名同时感染人类免疫缺陷病毒和2型单纯疱疹病毒（HSV-2）的男性进行了一项前瞻性观察研究，以评估其性伴侣因男性包皮环切术（MC）伤口而感染HSV-2的风险是否增加。术前和每周的阴茎灌洗样本均检测阴茎HSV-2脱落情况。使用泊松回归估计患病率风险比（PRR）。MC前，9.7%（176名中的17名）男性阴茎有可检测到的HSV-2脱落，相比之下，MC后1周时为12.9%（170名中的22名）（PRR，1.33；95%置信区间[CI]，0.74 - 2.38），2周时为14.8%（155名中的23名）（PRR，1.50；95%CI，0.86 - 2.62）。MC伤口愈合的男性中HSV-2脱落率较低（调整后的PRR，0.62；95%CI，0.35 - 1.08）。应对接受MC的男性进行性禁欲和使用避孕套的咨询。
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