Nopp A, Cardell L O, Johansson S G O, Oman H
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden.
Allergy. 2009 May;64(5):811-4. doi: 10.1111/j.1398-9995.2008.01900.x. Epub 2009 Feb 13.
Allergen-specific immunotherapy (ASIT) in allergic rhinitis and asthma is the only treatment that effects the long-term development of these diseases. Basophil allergen threshold sensitivity, CD-sens, which is a valuable complement to resource-demanding clinical challenge tests, was used to monitor the initiation of ASIT induced allergen 'blocking activity'.
Patients IgE-sensitized to timothy (n = 14) or birch (n = 19) pollen were started on conventional (8-16 weeks) or ultra rush ASIT, respectively, and followed by measurements of CD-sens, allergen binding activity (ABA) and serum IgG4- and IgE-antibody concentrations.
CD-sens decreased during the early phase of ASIT-treatment. In parallel, ABA increased and correlated significantly with the increasing levels of IgG4 antibody concentrations. High dosages of allergen were more effective while mode of dosing up did not seem to matter. No change was seen in basophil reactivity.
CD-sens and ABA, in contrast to basophil reactivity, seem to be promising tools to monitor protective immune responses initiated by ASIT.
变应性鼻炎和哮喘的变应原特异性免疫疗法（ASIT）是唯一能影响这些疾病长期发展的治疗方法。嗜碱性粒细胞变应原阈值敏感性（CD-sens）是对要求较高的临床激发试验的一种有价值的补充，用于监测ASIT诱导的变应原“阻断活性”的起始情况。
对梯牧草（n = 14）或桦树（n = 19）花粉IgE致敏的患者分别开始常规（8 - 16周）或超快速ASIT治疗，随后测量CD-sens、变应原结合活性（ABA）以及血清IgG4和IgE抗体浓度。
在ASIT治疗的早期阶段，CD-sens降低。同时，ABA升高且与IgG4抗体浓度的升高显著相关。高剂量变应原更有效，而给药方式似乎无关紧要。嗜碱性粒细胞反应性未见变化。
与嗜碱性粒细胞反应性不同，CD-sens和ABA似乎是监测ASIT引发的保护性免疫反应的有前景的工具。
