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孕期导致产后创伤后应激障碍和抑郁症的风险因素。

Risk factors in pregnancy for post-traumatic stress and depression after childbirth.

作者信息

Söderquist J, Wijma B, Thorbert G, Wijma K

机构信息

Department of Welfare and Social Studies (ISV), Linköping University, Campus Norrköping, Norrköping, Sweden.

出版信息

BJOG. 2009 Apr;116(5):672-80. doi: 10.1111/j.1471-0528.2008.02083.x. Epub 2009 Feb 10.

Abstract

OBJECTIVE

The objective of this study was to find risk factors in pregnancy for post-traumatic stress and depression 1 month after childbirth. Furthermore, the relation between post-traumatic stress and depression was explored.

DESIGN

A prospective longitudinal study.

SETTING

Pregnant women in Linköping and Kalmar, Sweden.

POPULATION

A total of 1224 women were assessed in pregnancy, week 12-20 and 32, as well as 1 month postpartum.

METHODS

Post-traumatic stress and depression after delivery were assessed 1 month postpartum. Potential risk factors were assessed in early and late pregnancy. Variables measured during pregnancy were trait anxiety, depression, fear of childbirth, childbirth-related traumatic stress, stress coping capacity, social support, parity, educational level, age, gestation week, parity, educational level, civil status, previous psychological/psychiatric counselling, and previous experience of any traumatic events. Delivery mode was assessed from the medical records.

MAIN OUTCOME MEASURES

Prevalence of post-traumatic stress (criteria A, B, C, D, E, and F according to DSM-IV) and depression (Beck's depression inventory).

RESULTS

One month postpartum, 12 (1.3%) women had post-traumatic stress (met symptom criteria B, C, and D for post-traumatic stress disorder according to Diagnostic and statistical manual of mental disorders, 4th edition [DSM-IV]). The most important risk factors in pregnancy were depression in early pregnancy (OR=16.3), severe fear of childbirth (OR=6.2), and 'pre'-traumatic stress (in view of the forthcoming delivery) in late pregnancy (OR=12.5). The prevalence of depression was 5.6%. Post-traumatic stress and depression were positively related 1 month postpartum and were predicted by mainly the same factors.

CONCLUSIONS

Risk factors for post-traumatic stress and depression after childbirth can be assessed in early pregnancy. Post-traumatic stress and depression also seem to share the same underlying vulnerability factors.

摘要

目的

本研究的目的是找出产后1个月时创伤后应激障碍和抑郁症的孕期风险因素。此外,还探讨了创伤后应激障碍与抑郁症之间的关系。

设计

一项前瞻性纵向研究。

地点

瑞典林雪平及卡尔马的孕妇。

研究对象

共有1224名女性在孕期第12 - 20周、第32周以及产后1个月接受评估。

方法

产后1个月时评估分娩后的创伤后应激障碍和抑郁症情况。在孕早期和孕晚期评估潜在风险因素。孕期测量的变量包括特质焦虑、抑郁、分娩恐惧、与分娩相关的创伤性应激、应激应对能力、社会支持、产次、教育水平、年龄、孕周、产次、教育水平、婚姻状况、既往心理/精神咨询情况以及既往任何创伤事件经历。从病历中评估分娩方式。

主要观察指标

创伤后应激障碍(根据《精神疾病诊断与统计手册》第四版[DSM-IV]的A、B、C、D、E和F标准)和抑郁症(贝克抑郁量表)的患病率。

结果

产后1个月时,12名(1.3%)女性患有创伤后应激障碍(符合《精神疾病诊断与统计手册》第四版[DSM-IV]中创伤后应激障碍的症状标准B、C和D)。孕期最重要的风险因素是孕早期抑郁(比值比[OR]=16.3)、严重分娩恐惧(OR=6.2)以及孕晚期(鉴于即将分娩)的“预”创伤后应激(OR=12.5)。抑郁症患病率为5.6%。产后1个月时,创伤后应激障碍与抑郁症呈正相关,且主要由相同因素预测。

结论

产后创伤后应激障碍和抑郁症的风险因素可在孕早期进行评估。创伤后应激障碍和抑郁症似乎也有相同的潜在易患因素。

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